caa a22 4500 605477558 CHVBK 20210128100401.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00787-014-0543-x doi (NATIONALLICENCE)springer-10.1007/s00787-014-0543-x The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods [Elektronische Daten] [Andrea Dietrich, Thomas Fernandez, Robert King, Matthew State, Jay Tischfield, Pieter Hoekstra, Gary Heiman] Tourette syndrome (TS) is a neuropsychiatric disorder characterized by recurrent motor and vocal tics, often accompanied by obsessive-compulsive disorder and/or attention-deficit/hyperactivity disorder. While the evidence for a genetic contribution is strong, its exact nature has yet to be clarified fully. There is now mounting evidence that the genetic risks for TS include both common and rare variants and may involve complex multigenic inheritance or, in rare cases, a single major gene. Based on recent progress in many other common disorders with apparently similar genetic architectures, it is clear that large patient cohorts and open-access repositories will be essential to further advance the field. To that end, the large multicenter Tourette International Collaborative Genetics (TIC Genetics) study was established. The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent-child trios with non-familial tics. The clinical data and biomaterials (DNA, transformed cell lines, RNA) are part of a sharing repository located within the National Institute for Mental Health Center for Collaborative Genomics Research on Mental Disorders, USA, and will be made available to the broad scientific community. This resource will ultimately facilitate better understanding of the pathophysiology of TS and related disorders and the development of novel therapies. Here, we describe the objectives and methods of the TIC Genetics study as a reference for future studies from our group and to facilitate collaboration between genetics consortia in the field of TS. The Author(s), 2014 Genes nationallicence Methods nationallicence Multiplex families nationallicence Rare variants nationallicence Repository nationallicence Tourette syndrome nationallicence Trios nationallicence Dietrich Andrea Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut Fernandez Thomas Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA aut King Robert Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA aut State Matthew Department of Psychiatry, University of California, San Francisco, USA aut Tischfield Jay Department of Genetics, The Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Life Science Building, 145 Bevier Road, 08854-8082, Piscataway, NJ, USA aut Hoekstra Pieter Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut Heiman Gary Department of Genetics, The Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Life Science Building, 145 Bevier Road, 08854-8082, Piscataway, NJ, USA aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/2(2015-02-01), 141-151 1018-8827 24:2<141 2015 24 787 https://doi.org/10.1007/s00787-014-0543-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0543-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dietrich Andrea Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Fernandez Thomas Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA aut NATIONALLICENCE 700 1- King Robert Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA aut NATIONALLICENCE 700 1- State Matthew Department of Psychiatry, University of California, San Francisco, USA aut NATIONALLICENCE 700 1- Tischfield Jay Department of Genetics, The Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Life Science Building, 145 Bevier Road, 08854-8082, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Hoekstra Pieter Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Heiman Gary Department of Genetics, The Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Life Science Building, 145 Bevier Road, 08854-8082, Piscataway, NJ, USA aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/2(2015-02-01), 141-151 1018-8827 24:2<141 2015 24 787