Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome

Verfasser / Beitragende:
[Mart Eussen, Esther de Bruin, Arthur Van Gool, Anneke Louwerse, Jan van der Ende, Fop Verheij, Frank Verhulst, Kirstin Greaves-Lord]
Ort, Verlag, Jahr:
2015
Enthalten in:
European Child & Adolescent Psychiatry, 24/2(2015-02-01), 163-172
Format:
Artikel (online)
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024 7 0 |a 10.1007/s00787-014-0552-9  |2 doi 
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245 0 0 |a Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome  |h [Elektronische Daten]  |c [Mart Eussen, Esther de Bruin, Arthur Van Gool, Anneke Louwerse, Jan van der Ende, Fop Verheij, Frank Verhulst, Kirstin Greaves-Lord] 
520 3 |a Formal thought disorder (FTD) is a disruption in the flow of thought, which is inferred from disorganisation of spoken language. FTD in autism spectrum disorders (ASD) might be a precursor of psychotic disorders or a manifestation of ASD symptom severity. The current longitudinal study is a seven-year follow-up of 91 individuals aged 5-12years with ASD. We tested (1) whether childhood FTD predicted prodromal symptoms of psychosis in adolescence and (2) whether childhood FTD was associated with greater ASD symptom severity in adolescence. ASD symptom severity was assessed in childhood (T1) and 7years later (T2), using the autism diagnostic observation schedule (ADOS). At T1, the Kiddie-Formal Thought Disorder Rating Scale (KFTDS) was used to measure symptoms of FTD. At T2, the prodromal questionnaire (PQ) was used to assess prodromal symptoms of psychosis. FTD at T1 did not predict prodromal symptoms of psychosis at T2 in children with ASD. FTD symptoms at T1, namely illogical thinking, predicted ASD symptom severity at T2 and this effect remained significant after controlling for T1 ASD symptom severity. In children with ASD, illogical thinking predicts severity of ASD symptoms in adolescence, but FTD does not predict prodromal symptoms of psychosis. 
540 |a Springer-Verlag Berlin Heidelberg, 2014 
690 7 |a Autism spectrum disorder  |2 nationallicence 
690 7 |a Longitudinal study  |2 nationallicence 
690 7 |a Psychotic symptoms  |2 nationallicence 
690 7 |a Thought disorder  |2 nationallicence 
690 7 |a Psychopathology  |2 nationallicence 
700 1 |a Eussen  |D Mart  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
700 1 |a de Bruin  |D Esther  |u Research Institute of Child Development and Education, University of Amsterdam, Nieuwe Prinsengracht 130, 1018 VZ, Amsterdam, The Netherlands  |4 aut 
700 1 |a Van Gool  |D Arthur  |u Department of Child and Adolescent Psychiatry, Autism Department, Yulius Mental Health, Yulius Academy, P.O Box 753, 3300 AT, Dordrecht, The Netherlands  |4 aut 
700 1 |a Louwerse  |D Anneke  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
700 1 |a van der Ende  |D Jan  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
700 1 |a Verheij  |D Fop  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
700 1 |a Verhulst  |D Frank  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
700 1 |a Greaves-Lord  |D Kirstin  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
773 0 |t European Child & Adolescent Psychiatry  |d Springer Berlin Heidelberg  |g 24/2(2015-02-01), 163-172  |x 1018-8827  |q 24:2<163  |1 2015  |2 24  |o 787 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Eussen  |D Mart  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a de Bruin  |D Esther  |u Research Institute of Child Development and Education, University of Amsterdam, Nieuwe Prinsengracht 130, 1018 VZ, Amsterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Van Gool  |D Arthur  |u Department of Child and Adolescent Psychiatry, Autism Department, Yulius Mental Health, Yulius Academy, P.O Box 753, 3300 AT, Dordrecht, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Louwerse  |D Anneke  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a van der Ende  |D Jan  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Verheij  |D Fop  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Verhulst  |D Frank  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Greaves-Lord  |D Kirstin  |u Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Rotterdam, Wytemaweg 8, 3015 CN, Rotterdam, The Netherlands  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t European Child & Adolescent Psychiatry  |d Springer Berlin Heidelberg  |g 24/2(2015-02-01), 163-172  |x 1018-8827  |q 24:2<163  |1 2015  |2 24  |o 787