caa a22 4500 605477647 CHVBK 20210128100402.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00787-014-0567-2 doi (NATIONALLICENCE)springer-10.1007/s00787-014-0567-2 Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour [Elektronische Daten] [Jennifer Richards, Catharina Hartman, Barbara Franke, Pieter Hoekstra, Dirk Heslenfeld, Jaap Oosterlaan, Alejandro Arias Vásquez, Jan Buitelaar] The differential susceptibility theory states that children differ in their susceptibility towards environmental experiences, partially due to plasticity genes. Individuals carrying specific variants in such genes will be more disadvantaged in negative but, conversely, more advantaged in positive environments. Understanding gene-environment interactions may help unravel the causal mechanisms involved in multifactorial psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD). The differential susceptibility theory was examined by investigating the presence of interaction effects between maternal expressed emotion (EE; warmth and criticism) and the solitary and combined effects of plasticity genes (DAT1, DRD4, 5-HTT) on prosocial and antisocial behaviour (measured with parent- and self-reports) in children with ADHD and their siblings (N=366, M=17.11years, 74.9% male). Maternal warmth was positively associated with prosocial behaviour and negatively with antisocial behaviour, while maternal criticism was positively associated with antisocial behaviour and negatively with prosocial behaviour. No evidence of differential susceptibility was found. The current study found no evidence for differential susceptibility based on the selected plasticity genes, in spite of strong EE-behaviour associations. It is likely that additional factors play a role in the complex relationship between genes, environment and behaviour. Springer-Verlag Berlin Heidelberg, 2014 Maternal expressed emotion nationallicence Antisocial behaviour nationallicence Prosocial behaviour nationallicence G×E interaction nationallicence Richards Jennifer Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut Hartman Catharina Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands aut Franke Barbara Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut Hoekstra Pieter Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands aut Heslenfeld Dirk Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands aut Oosterlaan Jaap Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands aut Arias Vásquez Alejandro Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut Buitelaar Jan Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/2(2015-02-01), 209-217 1018-8827 24:2<209 2015 24 787 https://doi.org/10.1007/s00787-014-0567-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-014-0567-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards Jennifer Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hartman Catharina Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Franke Barbara Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Hoekstra Pieter Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Heslenfeld Dirk Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Oosterlaan Jaap Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Arias Vásquez Alejandro Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Buitelaar Jan Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/2(2015-02-01), 209-217 1018-8827 24:2<209 2015 24 787