caa a22 4500 605477701 CHVBK 20210128100402.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00787-015-0686-4 doi (NATIONALLICENCE)springer-10.1007/s00787-015-0686-4 Affective processing bias in youth with primary bipolar disorder or primary attention-deficit/hyperactivity disorder [Elektronische Daten] [Karen Seymour, Kerri Kim, Grace Cushman, Megan Puzia, Alexandra Weissman, Thania Galvan, Daniel Dickstein] High rates of comorbidity and overlapping diagnostic criteria between pediatric bipolar disorder (BD) and attention-deficit/hyperactivity disorder (ADHD) contribute to diagnostic and treatment confusion. To advance what is known about both disorders, we compared effect of emotional stimuli on response control in children with primary BD, primary ADHD and typically developing controls (TDC). Participants included 7-17year olds with either "narrow-phenotype” pediatric BD (n=25), ADHD (n=25) or TDC (n=25). Groups were matched on participant age and FSIQ. The effect of emotional stimuli on response control was assessed using the Cambridge Neuropsychological Test Automated Battery Affective Go/No-Go task (CANTAB AGN). We found a group by target valence interaction on commission errors [F(2,71)=5.34, p<0.01, ƞ p 2 =0.13] whereby ADHD, but not TDC participants, made more errors on negative than positive words [t(24)=−2.58, p<0.05, r=0.47]. In contrast, there was a nonsignificant trend for BD participants to make fewer errors on negative versus positive words compared to ADHD and TDC participants. Between-subjects effects showed that ADHD participants made more errors than TDC, but not BD participants. Our main finding advances what is known about the effect of emotional stimuli on response control in children with ADHD. Our results suggesting a positive affective processing bias in children with ADHD compliment emerging literature show that difficulties with emotional processing and regulation may be core features of ADHD. Further, given the observed pattern of results in children with ADHD compared to BD children, our behavioral results suggest the importance of examining differences in the brain-behavior mechanisms involved in affective processing in children with ADHD compared to BD children. Springer-Verlag Berlin Heidelberg, 2015 Bipolar disorder nationallicence Attention-deficit/hyperactivity disorder nationallicence Affective processing nationallicence Emotion nationallicence Child psychiatry nationallicence Seymour Karen Divison of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, 550 North Broadway Street, Suite 943, 21205, Baltimore, MD, USA aut Kim Kerri Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut Cushman Grace Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut Puzia Megan Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut Weissman Alexandra Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut Galvan Thania Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut Dickstein Daniel Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/11(2015-11-01), 1349-1359 1018-8827 24:11<1349 2015 24 787 https://doi.org/10.1007/s00787-015-0686-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00787-015-0686-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seymour Karen Divison of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, 550 North Broadway Street, Suite 943, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Kim Kerri Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 700 1- Cushman Grace Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 700 1- Puzia Megan Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 700 1- Weissman Alexandra Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 700 1- Galvan Thania Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 700 1- Dickstein Daniel Bradley Hospital's Pediatric, Mood, Imaging and Neuro Developmental (PediMIND) Program, The Alpert Medical School of Brown University, Providence, USA aut NATIONALLICENCE 773 0- European Child & Adolescent Psychiatry Springer Berlin Heidelberg 24/11(2015-11-01), 1349-1359 1018-8827 24:11<1349 2015 24 787