caa a22 4500 605478597 CHVBK 20210128100406.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10741-014-9448-5 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9448-5 Efficacy of isolated left ventricular and biventricular pacing is differentially associated with baseline QRS duration in chronic heart failure: a meta-analysis of randomized controlled trials [Elektronische Daten] [Junyu Chen, Xiaodong Zhuang, Lizhen Liao, Xinxue Liao, Lichun Wang] Cardiac resynchronization therapy can treat chronic heart failure through either biventricular pacing (BVP) or isolated left ventricular pacing (LVP), and the efficacy is depended on QRS duration. However, the optimal therapeutic choice of pacing or how the QRS influences the efficacy remains uncertain. To investigate this uncertainty, we searched available publications in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials databases regarding differentials in efficacy parameters between BVP and LVP. A meta-analysis of eight randomized controlled trials found that BVP and LVP were comparable with regard to quality-of-life scores, left ventricular ejection fraction, left ventricular end-systolic volume, and mortality or heart transplant rates. However, there was a significant heterogeneity among the trials in 6-min walking distances. Subsequent meta-regression indicated that the baseline QRS duration significantly correlated with the standard mean difference between BVP and LVP. As QRS duration increased, the gain in 6-min walking distance with BVP became significantly greater than that of LVP. This suggests that it is necessary to consider the QRS duration when comparing the clinical effects of BVP and LVP. Springer Science+Business Media New York, 2014 Cardiac resynchronization therapy nationallicence Biventricular pacing nationallicence Left ventricular pacing nationallicence Chronic heart failure nationallicence QRS nationallicence Chen Junyu Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut Zhuang Xiaodong Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut Liao Lizhen Department of Health, Guangzhou Higher Education Mega Center, Guangdong Pharmaceutical University, 510006, Guangzhou, Guangdong, People's Republic of China aut Liao Xinxue Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut Wang Lichun Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/1(2015-01-01), 81-88 1382-4147 20:1<81 2015 20 10741 https://doi.org/10.1007/s10741-014-9448-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9448-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Junyu Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Zhuang Xiaodong Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Liao Lizhen Department of Health, Guangzhou Higher Education Mega Center, Guangdong Pharmaceutical University, 510006, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Liao Xinxue Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Wang Lichun Department of Cardiology, First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/1(2015-01-01), 81-88 1382-4147 20:1<81 2015 20 10741