caa a22 4500 605478600 CHVBK 20210128100406.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10741-014-9432-0 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9432-0 Thiamin deficiency and heart failure: the current knowledge and gaps in literature [Elektronische Daten] [Mavra Ahmed, Parastoo Azizi-Namini, Andrew Yan, Mary Keith] The management of heart failure (HF) represents a significant challenge for both patients as well as the healthcare system in industrialized countries. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. Therefore, thiamin deficiency (TD) may contribute to myocardial weakness by limiting the energy available for contraction. Previous studies have reported a wide range in the prevalence of TD in patients with HF (3-91%). The impact of thiamin supplementation in patients with HF is inconclusive. Studies conducted to date are limited by their small sample size, indirect methods of assessing thiamin concentration, methodological inconsistencies, use of impractical means of thiamin supplementation, a focus on hospitalized patients, and lack a robust technique for the assessment of cardiac function. Future large prospective studies and randomized controlled trials are needed to improve our understanding of any change in nutritional requirements associated with chronic disease as well as the clinical benefit of supplementation. Springer Science+Business Media New York, 2014 Vitamin B1 nationallicence Cardiac failure nationallicence Supplementation nationallicence LVEF nationallicence Ahmed Mavra Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut Azizi-Namini Parastoo Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut Yan Andrew Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut Keith Mary Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/1(2015-01-01), 1-11 1382-4147 20:1<1 2015 20 10741 https://doi.org/10.1007/s10741-014-9432-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9432-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ahmed Mavra Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Azizi-Namini Parastoo Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Yan Andrew Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Keith Mary Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/1(2015-01-01), 1-11 1382-4147 20:1<1 2015 20 10741