The short-term and long-term effects of tolvaptan in patients with heart failure: a meta-analysis of randomized controlled trials
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| 024 | 7 | 0 | |a 10.1007/s10741-015-9503-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10741-015-9503-x | ||
| 245 | 0 | 4 | |a The short-term and long-term effects of tolvaptan in patients with heart failure: a meta-analysis of randomized controlled trials |h [Elektronische Daten] |c [Bo Xiong, Yuwen Huang, Jie Tan, Yuanqing Yao, Chunbin Wang, Jun Qian, Shunkang Rong, Shimin Deng, Yin Cao, Yanke Zou, Jing Huang] |
| 520 | 3 | |a A comprehensive evaluation of the benefits of tolvaptan for the management of heart failure (HF) is lacking. The objective of this meta-analysis was to assess the short-term and long-term effects of tolvaptan in patients with HF. Articles were searched from PubMed, MEDLINE and Cochrane Library before March 31, 2015. Randomized controlled trials enrolling adult HF patients and reporting the all-cause mortality, cardiac events, body weight change or changes of serum electrolytes including sodium, potassium and creatinine were included in our meta-analysis. Ten studies covering 5574 patients met the inclusion criteria. Based on the data of meta-analysis, tolvaptan had no impact on the all-cause mortality [relative risk (RR) 0.96; 95% confidence interval (CI) 0.87-1.06; P=0.40] and incidence of cardiac events (RR 1.03; 95% CI 0.96-1.11; P=0.40) of HF patients. Furthermore, in comparison with control treatments, tolvaptan significantly decreased the body weight [weight mean difference (WMD), −0.87; 95% CI −1.03 to −0.71; P<0.001] and statistically increased serum sodium (WMD, 2.58; 95% CI −1.83 to 3.33; P<0.001) without any change in serum potassium (WMD, 0.01; 95% CI −0.03 to 0.05; P=0.577). However, serum creatinine may be increased slightly by tolvaptan (WMD, 0.05; 95% CI 0.03-0.07; P<0.001). This meta-analysis suggests that in HF patients, tolvaptan may not bring long-term benefits, but it effectively improves the volume overload and hyponatremia without obvious increases in serum potassium and creatinine. Hence, tolvaptan is likely to be a promising diuretic for the treatment of HF. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Tolvaptan |2 nationallicence | |
| 690 | 7 | |a Vasopressin v2 receptor antagonists |2 nationallicence | |
| 690 | 7 | |a Arginine vasopressin |2 nationallicence | |
| 690 | 7 | |a Heart failure |2 nationallicence | |
| 690 | 7 | |a Meta-analysis |2 nationallicence | |
| 700 | 1 | |a Xiong |D Bo |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Huang |D Yuwen |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Tan |D Jie |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Yao |D Yuanqing |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Wang |D Chunbin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Qian |D Jun |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Rong |D Shunkang |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Deng |D Shimin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Cao |D Yin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Zou |D Yanke |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 700 | 1 | |a Huang |D Jing |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | |
| 773 | 0 | |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/6(2015-11-01), 633-642 |x 1382-4147 |q 20:6<633 |1 2015 |2 20 |o 10741 | |
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| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xiong |D Bo |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Yuwen |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tan |D Jie |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yao |D Yuanqing |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Chunbin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Qian |D Jun |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rong |D Shunkang |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Deng |D Shimin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cao |D Yin |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zou |D Yanke |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Jing |u Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/6(2015-11-01), 633-642 |x 1382-4147 |q 20:6<633 |1 2015 |2 20 |o 10741 | ||