caa a22 4500 605478708 CHVBK 20210128100406.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10741-015-9503-x doi (NATIONALLICENCE)springer-10.1007/s10741-015-9503-x The short-term and long-term effects of tolvaptan in patients with heart failure: a meta-analysis of randomized controlled trials [Elektronische Daten] [Bo Xiong, Yuwen Huang, Jie Tan, Yuanqing Yao, Chunbin Wang, Jun Qian, Shunkang Rong, Shimin Deng, Yin Cao, Yanke Zou, Jing Huang] A comprehensive evaluation of the benefits of tolvaptan for the management of heart failure (HF) is lacking. The objective of this meta-analysis was to assess the short-term and long-term effects of tolvaptan in patients with HF. Articles were searched from PubMed, MEDLINE and Cochrane Library before March 31, 2015. Randomized controlled trials enrolling adult HF patients and reporting the all-cause mortality, cardiac events, body weight change or changes of serum electrolytes including sodium, potassium and creatinine were included in our meta-analysis. Ten studies covering 5574 patients met the inclusion criteria. Based on the data of meta-analysis, tolvaptan had no impact on the all-cause mortality [relative risk (RR) 0.96; 95% confidence interval (CI) 0.87-1.06; P=0.40] and incidence of cardiac events (RR 1.03; 95% CI 0.96-1.11; P=0.40) of HF patients. Furthermore, in comparison with control treatments, tolvaptan significantly decreased the body weight [weight mean difference (WMD), −0.87; 95% CI −1.03 to −0.71; P<0.001] and statistically increased serum sodium (WMD, 2.58; 95% CI −1.83 to 3.33; P<0.001) without any change in serum potassium (WMD, 0.01; 95% CI −0.03 to 0.05; P=0.577). However, serum creatinine may be increased slightly by tolvaptan (WMD, 0.05; 95% CI 0.03-0.07; P<0.001). This meta-analysis suggests that in HF patients, tolvaptan may not bring long-term benefits, but it effectively improves the volume overload and hyponatremia without obvious increases in serum potassium and creatinine. Hence, tolvaptan is likely to be a promising diuretic for the treatment of HF. Springer Science+Business Media New York, 2015 Tolvaptan nationallicence Vasopressin v2 receptor antagonists nationallicence Arginine vasopressin nationallicence Heart failure nationallicence Meta-analysis nationallicence Xiong Bo Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Huang Yuwen Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Tan Jie Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Yao Yuanqing Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Wang Chunbin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Qian Jun Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Rong Shunkang Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Deng Shimin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Cao Yin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Zou Yanke Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Huang Jing Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/6(2015-11-01), 633-642 1382-4147 20:6<633 2015 20 10741 https://doi.org/10.1007/s10741-015-9503-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9503-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xiong Bo Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Huang Yuwen Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Tan Jie Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Yao Yuanqing Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Wang Chunbin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Qian Jun Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Rong Shunkang Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Deng Shimin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Cao Yin Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Zou Yanke Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 700 1- Huang Jing Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, 400010, Chongqing, China aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/6(2015-11-01), 633-642 1382-4147 20:6<633 2015 20 10741