caa a22 4500 605478783 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10741-015-9506-7 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9506-7 Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review [Elektronische Daten] [Carolyn Lekavich, Debra Barksdale, Virginia Neelon, Jia-Rong Wu] In the USA, 5.7 million Americans ≥20years have heart failure (HF) and heart failure preserved ejection fraction (HFpEF) accounts for at least 50% of all hospital admissions for HF. HFpEF has no single guideline for diagnosis or treatment, the patient population is heterogeneously and inconsistently described, and longitudinal studies are lacking. The primary aims of this manuscript were to present an integrated review of the current state of the science on HFpEF, demonstrate gaps in the literature and provide the rationale for the design and implementation of future research to yield insights into the syndrome of HFpEF. The scientific literature was comprehensively reviewed on HFpEF pathophysiology, patient characteristics, diagnostic criteria, echocardiography biomarkers, treatment approaches and outcomes. Discrepancies in patient characteristics, diagnostic criteria, study methods and echocardiographic biomarkers were identified. This review indicates that no single test or guideline exists for diagnosis or treatment for HFpEF; heterogeneity of the population is complicated by multiple comorbidities that factor into etiology, race and age are likely important factors that define the phenotype, and limited information is available that designates early markers of impending HFpEF. Studies designed and adequately powered to study the impact of race and age along with consistent use of HFpEF diagnostic criteria are critically needed to further incident HFpEF research. Springer Science+Business Media New York, 2015 Heart failure preserved ejection fraction (HFpEF) nationallicence Diastolic heart failure nationallicence Treatment nationallicence Diagnostic guidelines nationallicence Lekavich Carolyn Division of Cardiovascular Medicine, Duke University Medical Center, Duke North, Erwin Road, Suite 7400, DUMC Box 3126, 27710, Durham, NC, USA aut Barksdale Debra School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut Neelon Virginia Biobehavioral Laboratory, School of Nursing, University of North Carolina, Chapel Hill, NC, USA aut Wu Jia-Rong School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/6(2015-11-01), 643-653 1382-4147 20:6<643 2015 20 10741 https://doi.org/10.1007/s10741-015-9506-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9506-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lekavich Carolyn Division of Cardiovascular Medicine, Duke University Medical Center, Duke North, Erwin Road, Suite 7400, DUMC Box 3126, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Barksdale Debra School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Neelon Virginia Biobehavioral Laboratory, School of Nursing, University of North Carolina, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Wu Jia-Rong School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/6(2015-11-01), 643-653 1382-4147 20:6<643 2015 20 10741