Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair
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| 024 | 7 | 0 | |a 10.1007/s10741-014-9465-4 |2 doi |
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| 245 | 0 | 0 | |a Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair |h [Elektronische Daten] |c [Constantinos Pantos, Iordanis Mourouzis] |
| 520 | 3 | |a Thyroid hormone (TH) appears to have a critical role in cardiac repair after injury beyond its role in development and metabolism homeostasis. This unique action is due to the fact that TH effect on the heart is shown to be differentiated depending on its administration on injured or healthy myocardium. Thus, TH can limit ischemia-reperfusion injury via a fine balance between pro-apoptotic and pro-survival signaling pathways. This response is thyroid hormone receptor (TRα1) dependent. Furthermore, an interaction between stress-induced growth kinase signaling and TRα1 is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. This new evidence is consistent with clinical observations showing the cardioprotective effect of TH treatment in cardiac surgery, transplantation and heart failure. TH and/or thyroid analogs may be novel agents in treating heart diseases. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Myocardial ischemia |2 nationallicence | |
| 690 | 7 | |a Heart failure |2 nationallicence | |
| 690 | 7 | |a Cardiac transplantation |2 nationallicence | |
| 690 | 7 | |a Thyroid hormone |2 nationallicence | |
| 690 | 7 | |a Thyroid hormone receptor α1 |2 nationallicence | |
| 700 | 1 | |a Pantos |D Constantinos |u Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece |4 aut | |
| 700 | 1 | |a Mourouzis |D Iordanis |u Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece |4 aut | |
| 773 | 0 | |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/3(2015-05-01), 273-282 |x 1382-4147 |q 20:3<273 |1 2015 |2 20 |o 10741 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10741-014-9465-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10741-014-9465-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pantos |D Constantinos |u Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mourouzis |D Iordanis |u Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/3(2015-05-01), 273-282 |x 1382-4147 |q 20:3<273 |1 2015 |2 20 |o 10741 | ||