caa a22 4500 605478791 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10741-014-9465-4 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9465-4 Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair [Elektronische Daten] [Constantinos Pantos, Iordanis Mourouzis] Thyroid hormone (TH) appears to have a critical role in cardiac repair after injury beyond its role in development and metabolism homeostasis. This unique action is due to the fact that TH effect on the heart is shown to be differentiated depending on its administration on injured or healthy myocardium. Thus, TH can limit ischemia-reperfusion injury via a fine balance between pro-apoptotic and pro-survival signaling pathways. This response is thyroid hormone receptor (TRα1) dependent. Furthermore, an interaction between stress-induced growth kinase signaling and TRα1 is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. This new evidence is consistent with clinical observations showing the cardioprotective effect of TH treatment in cardiac surgery, transplantation and heart failure. TH and/or thyroid analogs may be novel agents in treating heart diseases. Springer Science+Business Media New York, 2014 Myocardial ischemia nationallicence Heart failure nationallicence Cardiac transplantation nationallicence Thyroid hormone nationallicence Thyroid hormone receptor α1 nationallicence Pantos Constantinos Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece aut Mourouzis Iordanis Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 273-282 1382-4147 20:3<273 2015 20 10741 https://doi.org/10.1007/s10741-014-9465-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9465-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pantos Constantinos Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Mourouzis Iordanis Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., Goudi, 11527, Athens, Greece aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 273-282 1382-4147 20:3<273 2015 20 10741