caa a22 4500 605478813 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10741-014-9458-3 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9458-3 Hypertension: an unstudied potential risk factor for adverse outcomes during continuous flow ventricular assist device support [Elektronische Daten] [Lauren Wasson, Melana Yuzefpolskaya, Michiyori Wakabayashi, Hiroo Takayama, Yoshifumi Naka, Nir Uriel, Ulrich Jorde, Ryan Demmer, Paolo Colombo] In end-stage heart failure, left ventricular assist devices (LVADs) represent an exciting new frontier in which post-device implantation survival approaches that of heart transplant. However, expansion of this technology is still limited by complications that impact morbidity and mortality. Thus, it is essential to identify and optimize modifiable predictors of poor outcomes. One such predictor may be hypertension (HTN). Not only may chronic HTN as a traditional cardiovascular risk factor be present during long-term LVAD support, but HTN may also contribute to device malfunction or device-associated complications. Although current guidelines identify blood pressure (BP) control as important to outpatient continuous flow (CF) LVAD management, there is no evidence base to support these guidelines. Indeed, our comprehensive literature search did not identify any studies that evaluated post-device implantation HTN as a potential predictor of adverse CF-LVAD outcomes. HTN among CF-LVAD patients is likely a relatively unstudied factor because of difficulties using standard noninvasive techniques to measure BP in the setting of reduced pulsatile flow. Fortunately, recent research has elucidated the meaning of Doppler BP measurements and validated a slow-cuff deflation system for BP measurements in the setting of CF-LVAD support. Therefore, CF-LVAD researchers and clinicians may (1) consider potential mechanisms relating HTN to poor outcomes, (2) realize that HTN management is a stated goal despite scarce evidence, and (3) utilize the new reliable and valid methods for outpatient BP measurement that make research and management possible. It is critical and now feasible that research on HTN in the CF-LVAD patient population move forward. Springer Science+Business Media New York, 2014 Hypertension nationallicence Blood pressure nationallicence Left ventricular assist devices nationallicence Outcomes nationallicence AI : Aortic insufficiency nationallicence BP : Blood pressure nationallicence CF : Continuous flow nationallicence DBP : Diastolic blood pressure nationallicence HTN : Hypertension nationallicence INTERMACS : Interagency Registry for Mechanically Assisted Circulatory Support nationallicence LVAD : Left ventricular assist device nationallicence MAP : Mean arterial pressure nationallicence PP : Pulse pressure nationallicence SBP : Systolic blood pressure nationallicence Wasson Lauren NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Yuzefpolskaya Melana NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Wakabayashi Michiyori NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Takayama Hiroo NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Naka Yoshifumi NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Uriel Nir NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Jorde Ulrich NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Demmer Ryan Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA aut Colombo Paolo NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 317-322 1382-4147 20:3<317 2015 20 10741 https://doi.org/10.1007/s10741-014-9458-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9458-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wasson Lauren NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Yuzefpolskaya Melana NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Wakabayashi Michiyori NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Takayama Hiroo NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Naka Yoshifumi NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Uriel Nir NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Jorde Ulrich NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 700 1- Demmer Ryan Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Colombo Paolo NewYork-Presbyterian, Columbia University Medical Center, 622 West 168th Street, PH12-134, 10032-3720, New York, NY, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 317-322 1382-4147 20:3<317 2015 20 10741