caa a22 4500 605478821 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10741-014-9467-2 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9467-2 Mineralocorticoid receptor antagonists as diuretics: Can congestive heart failure learn from liver failure? [Elektronische Daten] [Amirali Masoumi, Fernando Ortiz, Jai Radhakrishnan, Robert Schrier, Paolo Colombo] Despite significant improvements in diagnosis, understanding the pathophysiology and management of the patients with acute decompensated heart failure (ADHF), diuretic resistance, yet to be clearly defined, is a major hurdle. Secondary hyperaldosteronism is a pivotal factor in pathogenesis of sodium retention, refractory congestion in heart failure (HF) as well as diuretic resistance. In patients with decompensated cirrhosis who suffer from ascites, similar pathophysiological complications have been recognized. Administration of natriuretic doses of mineralocorticoid receptor antagonists (MRAs) has been well established in management of cirrhotic patients. However, this strategy in patients with ADHF has not been well studied. This article will discuss the potential use of natriuretic doses of MRAs to overcome the secondary hyperaldosteronism as an alternative diuretic regimen in patients with HF. Springer Science+Business Media New York, 2014 Heart failure nationallicence Cirrhosis nationallicence Hyperaldosteronism nationallicence Mineralocorticoid receptor antagonism nationallicence Refractory congestion nationallicence Masoumi Amirali Division of Cardiology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Ortiz Fernando Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Radhakrishnan Jai Division of Nephrology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Schrier Robert Division of Nephrology, University of Colorado School of Medicine, Aurora, CO, USA aut Colombo Paolo Division of Cardiology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 283-290 1382-4147 20:3<283 2015 20 10741 https://doi.org/10.1007/s10741-014-9467-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9467-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Masoumi Amirali Division of Cardiology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Ortiz Fernando Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Radhakrishnan Jai Division of Nephrology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Schrier Robert Division of Nephrology, University of Colorado School of Medicine, Aurora, CO, USA aut NATIONALLICENCE 700 1- Colombo Paolo Division of Cardiology, New York-Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 283-290 1382-4147 20:3<283 2015 20 10741