caa a22 4500 605478856 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10741-014-9469-0 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9469-0 Exosome and its roles in cardiovascular diseases [Elektronische Daten] [Wang Zhao, Xi-Long Zheng, Shui-Ping Zhao] Exosomes are nanosized vesicles secreted by cells, which are capable of carrying signaling molecules in the forms of protein, mRNA and miRNA to serve as the platforms for complex intercellular communications. During the past few years, increasing efforts have been devoted to exosome research, and tremendous progress has been made in terms of identifying the molecular composition, elucidating the mechanisms and regulations of biogenesis and characterizing the functions in a variety of physiological and pathological settings including cardiovascular diseases, a leading cause of morbidity and mortality in modern society. This review provides an update on exosome research and summarizes the roles of exosomes in cardiovascular diseases. Springer Science+Business Media New York, 2014 Exosome nationallicence Intercellular communications nationallicence Biogenesis nationallicence Cardiovascular diseases nationallicence Zhao Wang Department of Cardiology, The Second Xiangya Hospital, Central South University, No. 139, People Street, 410011, Changsha, Hunan, China aut Zheng Xi-Long Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, T2N 4N1, Calgary, AB, Canada aut Zhao Shui-Ping Department of Cardiology, The Second Xiangya Hospital, Central South University, No. 139, People Street, 410011, Changsha, Hunan, China aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 337-348 1382-4147 20:3<337 2015 20 10741 https://doi.org/10.1007/s10741-014-9469-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9469-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Wang Department of Cardiology, The Second Xiangya Hospital, Central South University, No. 139, People Street, 410011, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Zheng Xi-Long Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, T2N 4N1, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Zhao Shui-Ping Department of Cardiology, The Second Xiangya Hospital, Central South University, No. 139, People Street, 410011, Changsha, Hunan, China aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 337-348 1382-4147 20:3<337 2015 20 10741