caa a22 4500 605478864 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10741-015-9471-1 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9471-1 The relationship between arterial stiffness and heart failure with preserved ejection fraction: a systemic meta-analysis [Elektronische Daten] [Bryan Chow, Simon Rabkin] The objective is to investigate the relationship between arterial stiffness measured by arterial tonometry and echocardiographic indices of diastolic dysfunction—a basis for the diagnosis of heart failure with preserved ejection fraction (HFpEF). OvidSP Medline, Embase and PubMed were systematically searched. Eligible articles correlated arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV), carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx) or cardio-ankle vascular index (CAVI) with indices of diastolic dysfunction, E/A ratio, peak early mitral annular velocity (e′) and E/e′ ratio. Correlation coefficients were determined using a random-effects model. Twenty-seven studies with 6,626 patients were included. baPWV was significantly correlated with E/A ratio (r=−0.434, 95% CI −0.387 to −0.479), e′ (r=−0.499, 95% CI −0.448 to −0.548) and E/e′ ratio (r=0.372, 95% CI 0.251-0.481). cfPWV was significantly correlated with E/A ratio (r=−0.391, 95% CI −0.304 to −0.470) and E/e′ ratio (r=0.210, 95% CI 0.300-0.116), but not e′. AIx was significantly correlated with E/A ratio (r=−0.356, 95% CI −0.255 to −0.450), e′ (r=−0.313, 95% CI −0.195 to −0.423) and E/e′ ratio (r=0.321, 95% CI 0.250-0.388). CAVI was significantly correlated with E/A ratio (r=−0.405, CI −0.324 to −0.481), e′ (r=−0.449, 95% CI −0.340 to −0.630), but not E/e′. baPWV showed significantly greater correlation with diastolic dysfunction compared to most other tonometric techniques. Arterial stiffness measured by arterial tonometry is an indicator of diastolic dysfunction with baPWV demonstrated the most consistent and strongest association. These data suggest a refocusing on the impact of arterial stiffness on the left ventricle as a potential causative factor leading to HFpEF. Springer Science+Business Media New York, 2015 Heart failure with preserved ejection fraction nationallicence Arterial stiffness nationallicence Pulse wave velocity nationallicence Augmentation index nationallicence Cardio-ankle vascular index nationallicence Diastolic dysfunction nationallicence Meta-analysis nationallicence Chow Bryan Department of Medicine (Cardiology), University of British Columbia, Level 9 - 2775 Laurel St, V5Z 1M9, Vancouver, B.C., Canada aut Rabkin Simon Department of Medicine (Cardiology), University of British Columbia, Level 9 - 2775 Laurel St, V5Z 1M9, Vancouver, B.C., Canada aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 291-303 1382-4147 20:3<291 2015 20 10741 https://doi.org/10.1007/s10741-015-9471-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9471-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chow Bryan Department of Medicine (Cardiology), University of British Columbia, Level 9 - 2775 Laurel St, V5Z 1M9, Vancouver, B.C., Canada aut NATIONALLICENCE 700 1- Rabkin Simon Department of Medicine (Cardiology), University of British Columbia, Level 9 - 2775 Laurel St, V5Z 1M9, Vancouver, B.C., Canada aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/3(2015-05-01), 291-303 1382-4147 20:3<291 2015 20 10741