Transient outward potassium channel: a heart failure mediator
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| 024 | 7 | 0 | |a 10.1007/s10741-015-9474-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10741-015-9474-y | ||
| 245 | 0 | 0 | |a Transient outward potassium channel: a heart failure mediator |h [Elektronische Daten] |c [Qianwen He, Ying Feng, Yanggan Wang] |
| 520 | 3 | |a Transient outward K+ current (I to) plays a crucial role in shaping the early phase of repolarization and setting the plateau voltage level of action potential. As a result, it extensively affects membrane current flow in the plateau window. A great body of evidence illustrates a transmural gradient of I to within ventricular wall with much higher density in epicardial than endocardial myocytes, which is important for the physiological ventricular repolarization. In heart failure (HF), this gradient is diminished due to a greater reduction of I to in epicardial myocytes. This attenuates the transmural gradient of early repolarization, facilitating conduction of abnormal impulses originated in the epicardium. In addition, I to reduction prolongs action potential duration and increases intercellular Ca2+, thus affecting Ca2+ handling and the excitation-contraction coupling. Furthermore, increased intercellular Ca2+ could activate CaMKII and calcineurin whose role in cardiac hypertrophy and HF development has been well established. Based on the impact of I to reduction on electrical activity, signal conduction, calcium handling and cardiac function, restoration of I to is likely a potential therapeutic strategy for HF. In this review, we summarize the physiological and pathological role of cardiac I to channel and the potential impact of I to restoration on HF therapy with an emphasis of recent novel findings. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Transient outward potassium current |2 nationallicence | |
| 690 | 7 | |a Heart failure |2 nationallicence | |
| 690 | 7 | |a Ca2+ handling |2 nationallicence | |
| 690 | 7 | |a CaMKII |2 nationallicence | |
| 690 | 7 | |a Calcineurin |2 nationallicence | |
| 700 | 1 | |a He |D Qianwen |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | |
| 700 | 1 | |a Feng |D Ying |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | |
| 700 | 1 | |a Wang |D Yanggan |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | |
| 773 | 0 | |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/3(2015-05-01), 349-362 |x 1382-4147 |q 20:3<349 |1 2015 |2 20 |o 10741 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10741-015-9474-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10741-015-9474-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a He |D Qianwen |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Feng |D Ying |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Yanggan |u Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, 430071, Wuhan, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/3(2015-05-01), 349-362 |x 1382-4147 |q 20:3<349 |1 2015 |2 20 |o 10741 | ||