caa a22 4500 605478929 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10741-015-9481-z doi (NATIONALLICENCE)springer-10.1007/s10741-015-9481-z Left ventricular assist devices: a kidney's perspective [Elektronische Daten] [T. Tromp, N. de Jonge, J. Joles] The left ventricular assist device (LVAD) has become an established treatment option for patients with refractory heart failure. Many of these patients experience chronic kidney disease (CKD) due to chronic cardiorenal syndrome type II, which is often alleviated quickly following LVAD implantation. Nevertheless, reversibility of CKD remains difficult to predict. Interestingly, initial recovery of GFR appears to be transient, being followed by gradual but significant late decline. Nevertheless, GFR often remains elevated compared to preimplant status. Larger GFR increases are followed by a proportionally larger late decline. Several explanations for this gradual decline in renal function after LVAD therapy have been proposed, yet a definitive answer remains elusive. Mortality predictors of LVAD implantation are the occurrence of either postimplantation acute kidney injury (AKI) or preimplant CKD. However, patient outcomes continue to improve as LVAD therapy becomes more widespread, and adverse events including AKI appear to decline. In light of a growing destination therapy population, it is important to understand the cumulative effects of long-term LVAD support on kidney function. Additional research and passage of time are required to further unravel the intricate relationships between the LVAD and the kidney. The Author(s), 2015 Left ventricular assist device nationallicence Renal function nationallicence Cardiorenal syndrome nationallicence Chronic kidney disease nationallicence Acute kidney injury nationallicence Mechanical circulatory support nationallicence Tromp T. University Medical Center Utrecht, POB 85500, 3508 GA, Utrecht, The Netherlands aut de Jonge N. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands aut Joles J. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 519-532 1382-4147 20:4<519 2015 20 10741 https://doi.org/10.1007/s10741-015-9481-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9481-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tromp T. University Medical Center Utrecht, POB 85500, 3508 GA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- de Jonge N. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Joles J. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 519-532 1382-4147 20:4<519 2015 20 10741