caa a22 4500 605478937 CHVBK 20210128100407.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10741-015-9476-9 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9476-9 Reporting of patient-centred outcomes in heart failure trials: are patient preferences being ignored? [Elektronische Daten] [Jeanet Blom, Maya El Azzi, Daisy Wopereis, Liam Glynn, Christiane Muth, Mieke van Driel] Older people often suffer from multiple diseases. Therefore, universal cross-disease outcomes (e.g. functional status, quality of life, overall survival) are more relevant than disease-specific outcomes, and a range of potential outcomes are needed for medical decision-making. To assess how patient-relevant outcomes have penetrated randomized controlled trials (RCTs), reporting of these outcomes was reviewed in heart failure trials that included patients with multimorbidity. We systematically reviewed RCTs (Jan 2011-June 2012) and evaluated reported outcomes. Heart failure was chosen as condition of interest as this is common among older patients with multimorbidity. The main outcome was the proportion of RCTs reporting all-cause mortality, all-cause hospital admission, and outcomes in four domains of health, i.e. functional, signs and symptoms, psychological, and social domains. Of the 106 included RCTs, 50 (47%) reported all-cause mortality and cardiovascular mortality and 29 (27%) reported all-cause hospitalization and cardiovascular hospitalization. Of all trials, 68 (64%) measured outcomes in the functional domain, 80 (75%) in the domain of signs and symptoms, 65 (61%) in the psychological domain, and 59 (56%) in the social domain. Disease-specific instruments were more often used than non-disease-specific instruments. This review shows increasing attention for more patient-relevant outcomes; this is promising and indicates more awareness of the importance of a variety of outcomes desirable for patients. However, patients' individual goal attainments were universally absent. For continued progress in patient-centred care, efforts are needed to develop these outcomes, study their merits and pitfalls, and intensify their use in research. The Author(s), 2015 Heart failure nationallicence Patient-reported outcomes nationallicence Patient-centred nationallicence Multimorbidity nationallicence Blom Jeanet Department of Public Health and Primary Care (V0-P), Leiden University Medical Center, Postbox 9600, 2300 RC, Leiden, The Netherlands aut El Azzi Maya Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Australia aut Wopereis Daisy Department of Public Health and Primary Care (V0-P), Leiden University Medical Center, Postbox 9600, 2300 RC, Leiden, The Netherlands aut Glynn Liam Discipline of General Practice, School of Medicine, National University of Ireland Galway, Galway, Ireland aut Muth Christiane Institute of General Practice, Johann Wolfgang Goethe University, Frankfurt am Main, Germany aut van Driel Mieke Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Australia aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 385-392 1382-4147 20:4<385 2015 20 10741 https://doi.org/10.1007/s10741-015-9476-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9476-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blom Jeanet Department of Public Health and Primary Care (V0-P), Leiden University Medical Center, Postbox 9600, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- El Azzi Maya Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Australia aut NATIONALLICENCE 700 1- Wopereis Daisy Department of Public Health and Primary Care (V0-P), Leiden University Medical Center, Postbox 9600, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Glynn Liam Discipline of General Practice, School of Medicine, National University of Ireland Galway, Galway, Ireland aut NATIONALLICENCE 700 1- Muth Christiane Institute of General Practice, Johann Wolfgang Goethe University, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- van Driel Mieke Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Australia aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 385-392 1382-4147 20:4<385 2015 20 10741