caa a22 4500 605478953 CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10741-015-9483-x doi (NATIONALLICENCE)springer-10.1007/s10741-015-9483-x Epigenetics of the failing heart [Elektronische Daten] [José Marín-García, Alexander Akhmedov] With the impressive advancement in high-throughput ‘omics' technologies over the past two decades, epigenetic mechanisms have emerged as the regulatory interface between the genome and environmental factors. These mechanisms include DNA methylation, histone modifications, ATP-dependent chromatin remodeling and RNA-based mechanisms. Their highly interdependent and coordinated action modulates the chromatin structure controlling access of the transcription machinery and thereby regulating expression of target genes. Given the rather limited proliferative capability of human cardiomyocytes, epigenetic regulation appears to play a particularly important role in the myocardium. The highly dynamic nature of the epigenome allows the heart to adapt to environmental challenges and to respond quickly and properly to cardiac stress. It is now becoming evident that histone-modifying and chromatin-remodeling enzymes as well as numerous non-coding RNAs play critical roles in cardiac development and function, while their dysregulation contributes to the onset and development of pathological cardiac remodeling culminating in HF. This review focuses on up-to-date knowledge about the epigenetic mechanisms and highlights their emerging role in the healthy and failing heart. Uncovering the determinants of epigenetic regulation holds great promise to accelerate the development of successful new diagnostic and therapeutic strategies in human cardiac disease. Springer Science+Business Media New York, 2015 CVD nationallicence HF epigenetics nationallicence DNA methylation nationallicence Histone modification nationallicence ATP-dependent chromatin remodeling nationallicence lncRNAs nationallicence Marín-García José The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Ave., 08904, Highland Park, NJ, USA aut Akhmedov Alexander The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Ave., 08904, Highland Park, NJ, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 435-459 1382-4147 20:4<435 2015 20 10741 https://doi.org/10.1007/s10741-015-9483-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9483-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marín-García José The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Ave., 08904, Highland Park, NJ, USA aut NATIONALLICENCE 700 1- Akhmedov Alexander The Molecular Cardiology and Neuromuscular Institute, 75 Raritan Ave., 08904, Highland Park, NJ, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 435-459 1382-4147 20:4<435 2015 20 10741