caa a22 4500 605479003 CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10741-015-9478-7 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9478-7 High salt intake as a multifaceted cardiovascular disease: new support from cellular and molecular evidence [Elektronische Daten] [Marcelo Baldo, Sérgio Rodrigues, José Mill] Scientists worldwide have disseminated the idea that increased dietary salt increases blood pressure. Currently, salt intake in the general population is ten times higher than that consumed in the past and at least two times higher than the current recommendation. Indeed, a salt-rich diet increases cardiovascular morbidity and mortality. For a long time, however, the deleterious effects associated with high salt consumption were only related to the effect of salt on blood pressure. Currently, several other effects have been reported. In some cases, the deleterious effects of high salt consumption are independently associated with other common risk factors. In this article, we gather data on the effects of increased salt intake on the cardiovascular system, from infancy to adulthood, to describe the route by which increased salt intake leads to cardiovascular diseases. We have reviewed the cellular and molecular mechanisms through which a high intake of salt acts on the cardiovascular system to lead to the progressive failure of a healthy heart. Springer Science+Business Media New York, 2015 Sodium nationallicence Hypertension nationallicence Hypertrophy nationallicence Cardiac remodeling nationallicence Salt sensitivity nationallicence Baldo Marcelo Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut Rodrigues Sérgio Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut Mill José Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 461-474 1382-4147 20:4<461 2015 20 10741 https://doi.org/10.1007/s10741-015-9478-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9478-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baldo Marcelo Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut NATIONALLICENCE 700 1- Rodrigues Sérgio Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut NATIONALLICENCE 700 1- Mill José Department of Physiological Sciences, Federal University of Espírito Santo, Av Marechal Campos 1468, Maruipe, 29042-755, Vitória, ES, Brazil aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 461-474 1382-4147 20:4<461 2015 20 10741