caa a22 4500 60547902X CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10741-015-9487-6 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9487-6 BAG3: a new player in the heart failure paradigm [Elektronische Daten] [Tijana Knezevic, Valerie Myers, Jennifer Gordon, Douglas Tilley, Thomas Sharp III, JuFang Wang, Kamel Khalili, Joseph Cheung, Arthur Feldman] BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous system. BAG3 functions in the cell include: serving as a co-chaperone with members of the heat-shock protein family of proteins to facilitate the removal of misfolded and degraded proteins, inhibiting apoptosis by interacting with Bcl2 and maintaining the structural integrity of the Z-disk in muscle by binding with CapZ. The importance of BAG3 in the homeostasis of myocytes and its role in the development of heart failure was evidenced by the finding that single allelic mutations in BAG3 were associated with familial dilated cardiomyopathy. Furthermore, significant decreases in the level of BAG3 have been found in end-stage failing human heart and in animal models of heart failure including mice with heart failure secondary to trans-aortic banding and in pigs after myocardial infarction. Thus, it becomes relevant to understand the cellular biology and molecular regulation of BAG3 expression in order to design new therapies for the treatment of patients with both hereditary and non-hereditary forms of dilated cardiomyopathy. The Author(s), 2015 BAG3 nationallicence Apoptosis nationallicence Autophagy nationallicence Knezevic Tijana Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Myers Valerie Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Gordon Jennifer Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Tilley Douglas Department of Pharmacology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Sharp III Thomas Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Wang JuFang Department of Medicine, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Khalili Kamel Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Cheung Joseph Department of Medicine, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Feldman Arthur Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 423-434 1382-4147 20:4<423 2015 20 10741 https://doi.org/10.1007/s10741-015-9487-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9487-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knezevic Tijana Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Myers Valerie Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Gordon Jennifer Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Tilley Douglas Department of Pharmacology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Sharp III Thomas Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Wang JuFang Department of Medicine, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Khalili Kamel Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Cheung Joseph Department of Medicine, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Feldman Arthur Department of Physiology, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/4(2015-07-01), 423-434 1382-4147 20:4<423 2015 20 10741