caa a22 4500 605479100 CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10741-015-9494-7 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9494-7 Cardiac stem cell therapy: Have we put too much hype in which cell type to use? [Elektronische Daten] [Jianqin Ye, Yerem Yeghiazarians] Injection of various stem cells has been tested with the hopes of improving cardiac function after a myocardial infarction (MI). However, there is continued controversy as to which cell type is best for repair. Due to technical differences in cell isolation, processing, delivery, and cardiac functional assessment by various investigators, it has been difficult to directly compare the results of different cells. Using same techniques to evaluate the efficacy of different cell types, we have separately delivered bone marrow cells (BMCs), cardiospheres (CSs), CS-derived Sca-1+/CD45− cells, human embryonic stem cell-derived cardiomyocytes, and BMC extract into infarcted murine myocardium and found that all of these treatments reduce infarct size and improve cardiac function post-MI similarly without one regimen being superior to another. The beneficial effects appear to be via paracrine influences. Different progenitors lead to improved cardiac function post-MI, but it is premature to hype any specific cell type at this time. Springer Science+Business Media New York, 2015 Cardiac progenitor cells nationallicence Bone marrow cells nationallicence Cardiosphere nationallicence Human embryonic stem cells nationallicence Cell therapy nationallicence Ye Jianqin Division of Cardiology, Department of Medicine, University of California, 94143, San Francisco, CA, USA aut Yeghiazarians Yerem Division of Cardiology, Department of Medicine, University of California, 94143, San Francisco, CA, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/5(2015-09-01), 613-619 1382-4147 20:5<613 2015 20 10741 https://doi.org/10.1007/s10741-015-9494-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9494-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ye Jianqin Division of Cardiology, Department of Medicine, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Yeghiazarians Yerem Division of Cardiology, Department of Medicine, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/5(2015-09-01), 613-619 1382-4147 20:5<613 2015 20 10741