Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection
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| 024 | 7 | 0 | |a 10.1007/s10741-015-9497-4 |2 doi |
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| 245 | 0 | 0 | |a Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection |h [Elektronische Daten] |c [Rosalinda Madonna, Christian Cadeddu, Martino Deidda, Donato Mele, Ines Monte, Giuseppina Novo, Pasquale Pagliaro, Alessia Pepe, Paolo Spallarossa, Carlo Tocchetti, Concetta Zito, Giuseppe Mercuro] |
| 520 | 3 | |a Although treatment for heart failure induced by cancer therapy has improved in recent years, the prevalence of cardiomyopathy due to antineoplastic therapy remains significant worldwide. In addition to traditional mediators of myocardial damage, such as reactive oxygen species, new pathways and target cells should be considered responsible for the impairment of cardiac function during anticancer treatment. Accordingly, there is a need to develop novel therapeutic strategies to protect the heart from pharmacologic injury, and improve clinical outcomes in cancer patients. The development of novel protective therapies requires testing putative therapeutic strategies in appropriate animal models of chemotherapy-induced cardiomyopathy. This Position Paper of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology aims to: (1) define the distinctive etiopatogenetic features of cardiac toxicity induced by cancer therapy in humans, which include new aspects of mitochondrial function and oxidative stress, neuregulin-1 modulation through the ErbB receptor family, angiogenesis inhibition, and cardiac stem cell depletion and/or dysfunction; (2) review the new, more promising therapeutic strategies for cardioprotection, aimed to increase the survival of patients with severe antineoplastic-induced cardiotoxicity; (3) recommend the distinctive pathological features of cardiotoxicity induced by cancer therapy in humans that should be present in animal models used to identify or to test new cardioprotective therapies. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Cancer therapy-induced cardiac injury |2 nationallicence | |
| 690 | 7 | |a Preclinical models |2 nationallicence | |
| 690 | 7 | |a Cardioprotection |2 nationallicence | |
| 690 | 7 | |a Mitochondria |2 nationallicence | |
| 690 | 7 | |a Neuregulin-1 |2 nationallicence | |
| 690 | 7 | |a Oxidative stress |2 nationallicence | |
| 690 | 7 | |a Statins |2 nationallicence | |
| 690 | 7 | |a Beta-blockers |2 nationallicence | |
| 690 | 7 | |a ACE inhibitors |2 nationallicence | |
| 690 | 7 | |a Cardiac stem cells |2 nationallicence | |
| 690 | 7 | |a CHF : Congestive heart failure |2 nationallicence | |
| 690 | 7 | |a ROS : Reactive oxygen species |2 nationallicence | |
| 690 | 7 | |a NRG-1 : Neuregulin-1 |2 nationallicence | |
| 690 | 7 | |a Top2 : Topoisomerase II |2 nationallicence | |
| 690 | 7 | |a PI3 : Phosphoinositide-3 |2 nationallicence | |
| 690 | 7 | |a AKT : Protein kinase B |2 nationallicence | |
| 690 | 7 | |a MEK/ERK : Mitogen extracellular kinase |2 nationallicence | |
| 690 | 7 | |a TK : Tyrosine kinase |2 nationallicence | |
| 690 | 7 | |a VEGFR : Vascular endothelial growth factor receptor |2 nationallicence | |
| 690 | 7 | |a PDGFR : Platelet-derived growth factor receptor |2 nationallicence | |
| 690 | 7 | |a CSCs : Cardiac stem cells |2 nationallicence | |
| 690 | 7 | |a CPCs : Cardiac progenitor cells |2 nationallicence | |
| 690 | 7 | |a ACE : Angiotensin-converting enzyme |2 nationallicence | |
| 700 | 1 | |a Madonna |D Rosalinda |u Center of Excellence on Aging, Institute of Cardiology, "G. d'Annunzio” University - Chieti, Chieti, Italy |4 aut | |
| 700 | 1 | |a Cadeddu |D Christian |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | |
| 700 | 1 | |a Deidda |D Martino |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | |
| 700 | 1 | |a Mele |D Donato |u Cardiology Unit, University Hospital of Ferrara, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Monte |D Ines |u Department of General Surgery and Medical-Surgery Specialties, University of Catania, Catania, Italy |4 aut | |
| 700 | 1 | |a Novo |D Giuseppina |u Chair and Division of Cardiology, University of Palermo, Palermo, Italy |4 aut | |
| 700 | 1 | |a Pagliaro |D Pasquale |u Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy |4 aut | |
| 700 | 1 | |a Pepe |D Alessia |u U.O.C. Magnetic Resonance Imaging, Fondazione G. Monasterio C.N.R., Pisa, Italy |4 aut | |
| 700 | 1 | |a Spallarossa |D Paolo |u Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy |4 aut | |
| 700 | 1 | |a Tocchetti |D Carlo |u Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy |4 aut | |
| 700 | 1 | |a Zito |D Concetta |u U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico "G. Martino”, University of Messina, Messina, Italy |4 aut | |
| 700 | 1 | |a Mercuro |D Giuseppe |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | |
| 773 | 0 | |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/5(2015-09-01), 621-631 |x 1382-4147 |q 20:5<621 |1 2015 |2 20 |o 10741 | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10741-015-9497-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Madonna |D Rosalinda |u Center of Excellence on Aging, Institute of Cardiology, "G. d'Annunzio” University - Chieti, Chieti, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cadeddu |D Christian |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Deidda |D Martino |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mele |D Donato |u Cardiology Unit, University Hospital of Ferrara, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Monte |D Ines |u Department of General Surgery and Medical-Surgery Specialties, University of Catania, Catania, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Novo |D Giuseppina |u Chair and Division of Cardiology, University of Palermo, Palermo, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pagliaro |D Pasquale |u Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pepe |D Alessia |u U.O.C. Magnetic Resonance Imaging, Fondazione G. Monasterio C.N.R., Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spallarossa |D Paolo |u Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tocchetti |D Carlo |u Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zito |D Concetta |u U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico "G. Martino”, University of Messina, Messina, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mercuro |D Giuseppe |u Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Heart Failure Reviews |d Springer US; http://www.springer-ny.com |g 20/5(2015-09-01), 621-631 |x 1382-4147 |q 20:5<621 |1 2015 |2 20 |o 10741 | ||