caa a22 4500 605479119 CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10741-015-9497-4 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9497-4 Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection [Elektronische Daten] [Rosalinda Madonna, Christian Cadeddu, Martino Deidda, Donato Mele, Ines Monte, Giuseppina Novo, Pasquale Pagliaro, Alessia Pepe, Paolo Spallarossa, Carlo Tocchetti, Concetta Zito, Giuseppe Mercuro] Although treatment for heart failure induced by cancer therapy has improved in recent years, the prevalence of cardiomyopathy due to antineoplastic therapy remains significant worldwide. In addition to traditional mediators of myocardial damage, such as reactive oxygen species, new pathways and target cells should be considered responsible for the impairment of cardiac function during anticancer treatment. Accordingly, there is a need to develop novel therapeutic strategies to protect the heart from pharmacologic injury, and improve clinical outcomes in cancer patients. The development of novel protective therapies requires testing putative therapeutic strategies in appropriate animal models of chemotherapy-induced cardiomyopathy. This Position Paper of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology aims to: (1) define the distinctive etiopatogenetic features of cardiac toxicity induced by cancer therapy in humans, which include new aspects of mitochondrial function and oxidative stress, neuregulin-1 modulation through the ErbB receptor family, angiogenesis inhibition, and cardiac stem cell depletion and/or dysfunction; (2) review the new, more promising therapeutic strategies for cardioprotection, aimed to increase the survival of patients with severe antineoplastic-induced cardiotoxicity; (3) recommend the distinctive pathological features of cardiotoxicity induced by cancer therapy in humans that should be present in animal models used to identify or to test new cardioprotective therapies. Springer Science+Business Media New York, 2015 Cancer therapy-induced cardiac injury nationallicence Preclinical models nationallicence Cardioprotection nationallicence Mitochondria nationallicence Neuregulin-1 nationallicence Oxidative stress nationallicence Statins nationallicence Beta-blockers nationallicence ACE inhibitors nationallicence Cardiac stem cells nationallicence CHF : Congestive heart failure nationallicence ROS : Reactive oxygen species nationallicence NRG-1 : Neuregulin-1 nationallicence Top2 : Topoisomerase II nationallicence PI3 : Phosphoinositide-3 nationallicence AKT : Protein kinase B nationallicence MEK/ERK : Mitogen extracellular kinase nationallicence TK : Tyrosine kinase nationallicence VEGFR : Vascular endothelial growth factor receptor nationallicence PDGFR : Platelet-derived growth factor receptor nationallicence CSCs : Cardiac stem cells nationallicence CPCs : Cardiac progenitor cells nationallicence ACE : Angiotensin-converting enzyme nationallicence Madonna Rosalinda Center of Excellence on Aging, Institute of Cardiology, "G. d'Annunzio” University - Chieti, Chieti, Italy aut Cadeddu Christian Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut Deidda Martino Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut Mele Donato Cardiology Unit, University Hospital of Ferrara, Ferrara, Italy aut Monte Ines Department of General Surgery and Medical-Surgery Specialties, University of Catania, Catania, Italy aut Novo Giuseppina Chair and Division of Cardiology, University of Palermo, Palermo, Italy aut Pagliaro Pasquale Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy aut Pepe Alessia U.O.C. Magnetic Resonance Imaging, Fondazione G. Monasterio C.N.R., Pisa, Italy aut Spallarossa Paolo Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy aut Tocchetti Carlo Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy aut Zito Concetta U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico "G. Martino”, University of Messina, Messina, Italy aut Mercuro Giuseppe Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/5(2015-09-01), 621-631 1382-4147 20:5<621 2015 20 10741 https://doi.org/10.1007/s10741-015-9497-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9497-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madonna Rosalinda Center of Excellence on Aging, Institute of Cardiology, "G. d'Annunzio” University - Chieti, Chieti, Italy aut NATIONALLICENCE 700 1- Cadeddu Christian Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut NATIONALLICENCE 700 1- Deidda Martino Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut NATIONALLICENCE 700 1- Mele Donato Cardiology Unit, University Hospital of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Monte Ines Department of General Surgery and Medical-Surgery Specialties, University of Catania, Catania, Italy aut NATIONALLICENCE 700 1- Novo Giuseppina Chair and Division of Cardiology, University of Palermo, Palermo, Italy aut NATIONALLICENCE 700 1- Pagliaro Pasquale Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy aut NATIONALLICENCE 700 1- Pepe Alessia U.O.C. Magnetic Resonance Imaging, Fondazione G. Monasterio C.N.R., Pisa, Italy aut NATIONALLICENCE 700 1- Spallarossa Paolo Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy aut NATIONALLICENCE 700 1- Tocchetti Carlo Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy aut NATIONALLICENCE 700 1- Zito Concetta U.O.C. Cardiology Intensive Unit, A.O.U. Policlinico "G. Martino”, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Mercuro Giuseppe Department of Medical Sciences "Mario Aresu”, University of Cagliari, Cagliari, Italy aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/5(2015-09-01), 621-631 1382-4147 20:5<621 2015 20 10741