caa a22 4500 605479143 CHVBK 20210128100408.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10741-014-9456-5 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9456-5 Radionuclide imaging of cardiac sympathetic innervation in heart failure: unlocking untapped potential [Elektronische Daten] [Shuchita Gupta, Aman Amanullah] Heart failure (HF) is associated with sympathetic overactivity, which contributes to disease progression and arrhythmia development. Cardiac sympathetic innervation imaging can be performed using radiotracers that are taken up in the presynaptic nerve terminal of sympathetic nerves. The commonly used radiotracers are 123I-metaiodobenzylguanidine (123I-mIBG) for planar and single-photon emission computed tomography imaging, and 11C-hydroxyephedrine for positron emission tomography imaging. Sympathetic innervation imaging has been used in assessing prognosis, response to treatment, risk of ventricular arrhythmias and sudden death and prediction of response to cardiac resynchronization therapy in patients with HF. Other potential applications of these techniques are in patients with chemotherapy-induced cardiomyopathy, predicting myocardial recovery in patients with left ventricular assist devices, and assessing reinnervation following cardiac transplantation. There is a lack of standardization with respect to technique of 123I-mIBG imaging that needs to be overcome for the imaging modality to gain popularity in clinical practice. Springer Science+Business Media New York, 2014 Cardiac sympathetic innervation nationallicence 123I-Metaiodobenzylguanidine nationallicence 11C-Hydroxyephedrine nationallicence Positron emission tomography (PET) nationallicence Gupta Shuchita Einstein Institute for Heart and Vascular Health, Einstein Medical Center, 5501 Old York Road, 3rd Floor Levy Building, 19141, Philadelphia, PA, USA aut Amanullah Aman Einstein Institute for Heart and Vascular Health, Einstein Medical Center, 5501 Old York Road, 3rd Floor Levy Building, 19141, Philadelphia, PA, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 215-226 1382-4147 20:2<215 2015 20 10741 https://doi.org/10.1007/s10741-014-9456-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9456-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupta Shuchita Einstein Institute for Heart and Vascular Health, Einstein Medical Center, 5501 Old York Road, 3rd Floor Levy Building, 19141, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Amanullah Aman Einstein Institute for Heart and Vascular Health, Einstein Medical Center, 5501 Old York Road, 3rd Floor Levy Building, 19141, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 215-226 1382-4147 20:2<215 2015 20 10741