caa a22 4500 605479208 CHVBK 20210128100409.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10741-015-9480-0 doi (NATIONALLICENCE)springer-10.1007/s10741-015-9480-0 Cardiac amyloidosis: the great pretender [Elektronische Daten] [Claudio Rapezzi, Massimiliano Lorenzini, Simone Longhi, Agnese Milandri, Christian Gagliardi, Ilaria Bartolomei, Fabrizio Salvi, Mathew Maurer] Cardiac amyloidosis (CA) is often misdiagnosed because of both physician-related and disease-related reasons including: fragmented knowledge among different specialties and subspecialties, shortage of centres and specialists dedicated to disease management, erroneous belief it is an incurable disease, rarity of the condition, intrinsic phenotypic heterogeneity, genotypic heterogeneity in transthyretin-related forms and the necessity of target organ tissue histological diagnosis in the vast majority of cases. Pitfalls, incorrect beliefs and deceits challenge not only the path to the diagnosis of CA but also the precise identification of aetiological subtype. The awareness of this condition is the most important prerequisite for the management of the risk of underdiagnoses and misdiagnosis. Almost all clinical, imaging and laboratory tests can be misinterpreted, but fortunately each of these diagnostic steps can also offer diagnostic "red flags” (i.e. highly suggestive findings that can foster the correct diagnostic suspicion and facilitate early, timely diagnosis). This is especially important because outcomes in CA are largely driven by the severity of cardiac dysfunction and emerging therapies are aimed at preventing further amyloid deposition. Springer Science+Business Media New York, 2015 Amyloidosis nationallicence Transthyretin nationallicence Cardiomyopathy nationallicence Senile systemic amyloidosis nationallicence Familial amyloid polyneuropathy nationallicence Diagnosis nationallicence Rapezzi Claudio Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut Lorenzini Massimiliano Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut Longhi Simone Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut Milandri Agnese Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut Gagliardi Christian Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut Bartolomei Ilaria IRCCS Neurosciences, Bologna, Italy aut Salvi Fabrizio IRCCS Neurosciences, Bologna, Italy aut Maurer Mathew Center for Advanced Cardiac Care, Columbia College of Physicians and Surgeons, New York City, NY, USA aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 117-124 1382-4147 20:2<117 2015 20 10741 https://doi.org/10.1007/s10741-015-9480-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-015-9480-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rapezzi Claudio Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Lorenzini Massimiliano Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Longhi Simone Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Milandri Agnese Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Gagliardi Christian Cardiology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Alma Mater Studiorum, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Bartolomei Ilaria IRCCS Neurosciences, Bologna, Italy aut NATIONALLICENCE 700 1- Salvi Fabrizio IRCCS Neurosciences, Bologna, Italy aut NATIONALLICENCE 700 1- Maurer Mathew Center for Advanced Cardiac Care, Columbia College of Physicians and Surgeons, New York City, NY, USA aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 117-124 1382-4147 20:2<117 2015 20 10741