caa a22 4500 605479216 CHVBK 20210128100409.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10741-014-9470-7 doi (NATIONALLICENCE)springer-10.1007/s10741-014-9470-7 Cardiovascular magnetic resonance for amyloidosis [Elektronische Daten] [Marianna Fontana, Robin Chung, Philip Hawkins, James Moon] Cardiac involvement drives the prognosis and treatment in systemic amyloid. Echocardiography, the mainstay of current cardiac imaging, defines cardiac structure and function. Echocardiography, in conjunction with clinical phenotype, electrocardiogram and biomarkers (brain natriuretic peptide and troponin), provides an assessment of the likelihood and extent of cardiac involvement. Two tests are transforming our understanding of cardiac amyloidosis, bone tracer scanning and cardiovascular magnetic resonance (CMR). CMR provides a "second opinion” on the heart's structure and systolic function with better accuracy and more precision than echocardiography but is unable to assess diastolic function and is not as widely available. Where CMR adds unique advantages is in evaluating myocardial tissue characterisation. With administration of contrast, the latest type of late gadolinium enhancement imaging (phase-sensitive inversion recovery sequence) is highly sensitive and specific with images virtually pathognomonic for amyloidosis. CMR is also demonstrating that the range of structural and functional changes in cardiac amyloid is broader than traditionally thought. CMR with T1 mapping, a relatively new CMR technique, can measure the amyloid burden and the myocyte response to infiltration (hypertrophy/cell loss) with advantages for tracking change (e.g. the wall thickness can stay the same but the composition can change) over time or during therapy. Such techniques hold great promise for advancing drug development in this arena and providing new prognostic insights. CMR with tissue characterisation is rewriting our understanding of cardiac amyloidosis and may lead to the development of new classification, therapies and prognostic systems. Springer Science+Business Media New York, 2014 Amyloidosis nationallicence CMR nationallicence T1 mapping nationallicence Fontana Marianna The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut Chung Robin The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut Hawkins Philip National Amyloidosis Centre, Royal Free Hospital, University College London, London, UK aut Moon James The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 133-144 1382-4147 20:2<133 2015 20 10741 https://doi.org/10.1007/s10741-014-9470-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10741-014-9470-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fontana Marianna The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut NATIONALLICENCE 700 1- Chung Robin The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut NATIONALLICENCE 700 1- Hawkins Philip National Amyloidosis Centre, Royal Free Hospital, University College London, London, UK aut NATIONALLICENCE 700 1- Moon James The Heart Hospital Imaging Centre, 16-18 Westmoreland Street, W1G 8PH, London, UK aut NATIONALLICENCE 773 0- Heart Failure Reviews Springer US; http://www.springer-ny.com 20/2(2015-03-01), 133-144 1382-4147 20:2<133 2015 20 10741