caa a22 4500 605479283 CHVBK 20210128100409.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10544-014-9924-7 doi (NATIONALLICENCE)springer-10.1007/s10544-014-9924-7 In vitro release of cupric ion from intrauterine devices: influence of frame, shape, copper surface area and indomethacin [Elektronische Daten] [Shuangshuang Zhang, Ying Li, Panpan Yu, Tong Chen, Weisai Zhou, Wenli Zhang, Jianping Liu] The release of cupric ion from copper intrauterine device (Cu-IUD) in human uterus is essential for contraception. However, excessive cupric ion will cause cytotoxic effect. In this paper, we investigated the influence of device characteristics (frame, copper surface area, shape, copper type and indomethacin) on copper release for the efficacy and adverse effects vary with IUD types which may correlate to their different release behaviors. Nine types of Cu-IUDs were selected and incubated in simulated uterine fluid. They were paired for comparison based on the device properties and the release of cupric ion was determined by flame atomic absorption spectrometer for about 160days. The result showed that there was a burst release during the first month and the release rate tends to slow down and become steady afterwards. In addition, the copper release was mainly influenced by frame, indomethacin and copper type (copper wire and copper sleeve) while the shape variation had little effect on copper release throughout the experiment. Moreover, the influence of copper surface area was only noticeable during the first month. These findings were seldom reported before and may provide some useful information for the design of Cu-IUDs. Springer Science+Business Media New York, 2015 Cu-IUD nationallicence Cupric ion nationallicence Release behavior nationallicence Device characteristics nationallicence Zhang Shuangshuang Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Li Ying Jiangsu Institute of Planned Parenthood Research, 210036, Nanjing, China aut Yu Panpan Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Chen Tong Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Zhou Weisai Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Zhang Wenli Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Liu Jianping Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/1(2015-02-01), 1-7 1387-2176 17:1<1 2015 17 10544 https://doi.org/10.1007/s10544-014-9924-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-014-9924-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Shuangshuang Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Li Ying Jiangsu Institute of Planned Parenthood Research, 210036, Nanjing, China aut NATIONALLICENCE 700 1- Yu Panpan Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Chen Tong Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Zhou Weisai Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Zhang Wenli Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Liu Jianping Department of Pharmaceutics, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/1(2015-02-01), 1-7 1387-2176 17:1<1 2015 17 10544