caa a22 4500 605479305 CHVBK 20210128100409.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10544-014-9917-6 doi (NATIONALLICENCE)springer-10.1007/s10544-014-9917-6 An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model [Elektronische Daten] [Yaqian Liu, Peiyi Song, Jianwei Liu, Danny Tng, Rui Hu, Hongyan Chen, Yazhuo Hu, Cher Tan, Jianhua Wang, Jing Liu, Ling Ye, Ken-Tye Yong] The use of MEMS implantable drug delivery pump device enables one to program the desired drug delivery profile in the device for individualized medicine treatment to patients. In this study, a MEMS drug delivery device is prepared and employed for in vivo applications. 12 devices are implanted subcutaneously into Kunming mice for evaluating their long term biocompatibility and drug-delivery efficiency in vivo. All the mice survived after device implantation surgery procedures. Histological analysis result reveals a normal wound healing progression within the tissues-to-device contact areas. Serum analysis shows that all measured factors are within normal ranges and do not indicate any adverse responses associated with the implanted device. Phenylephrine formulation is chosen and delivered to the abdominal cavity of the mice by using either the implanted MEMS device (experimental group) or the syringe injection method (control group). Both groups show that they are able to precisely control and manipulate the increment rate of blood pressure in the small animals. Our result strongly suggests that the developed refillable implantable MEMS devices will serve as a viable option for future individualized medicine applications such as glaucoma, HIV-dementia and diabetes therapy. Springer Science+Business Media New York, 2015 Individualized medicine nationallicence Drug delivery nationallicence Implantable Device nationallicence Biocompatibility nationallicence In Vivo nationallicence Liu Yaqian Laboratory Animal Center of the Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Song Peiyi School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut Liu Jianwei Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Tng Danny School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut Hu Rui School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut Chen Hongyan Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Hu Yazhuo Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Tan Cher Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore, Singapore aut Wang Jianhua Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Liu Jing Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Ye Ling Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut Yong Ken-Tye School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/1(2015-02-01), 1-12 1387-2176 17:1<1 2015 17 10544 https://doi.org/10.1007/s10544-014-9917-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-014-9917-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Yaqian Laboratory Animal Center of the Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Song Peiyi School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut NATIONALLICENCE 700 1- Liu Jianwei Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Tng Danny School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut NATIONALLICENCE 700 1- Hu Rui School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut NATIONALLICENCE 700 1- Chen Hongyan Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Hu Yazhuo Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Tan Cher Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore, Singapore aut NATIONALLICENCE 700 1- Wang Jianhua Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Liu Jing Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Ye Ling Institute of Geriatrics and Beijing Key Lab of Aging and Geriatrics, Chinese PLA General Hospital, 100853, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Yong Ken-Tye School of Electrical and Electronic Engineering, Nanyang Technological University, 639798, Singapore, Singapore aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/1(2015-02-01), 1-12 1387-2176 17:1<1 2015 17 10544