Impedance characterization, degradation, and in vitro biocompatibility for platinum electrodes on BioMEMS
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| 024 | 7 | 0 | |a 10.1007/s10544-014-9909-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-014-9909-6 | ||
| 245 | 0 | 0 | |a Impedance characterization, degradation, and in vitro biocompatibility for platinum electrodes on BioMEMS |h [Elektronische Daten] |c [Thomas Geninatti, Giacomo Bruno, Bernardo Barile, R. Hood, Marco Farina, Jeffrey Schmulen, Giancarlo Canavese, Alessandro Grattoni] |
| 520 | 3 | |a Fine control of molecular transport through microfluidic systems can be obtained by modulation of an applied electrical field across channels with the use of electrodes. In BioMEMS designed for biological fluids and in vivo applications, electrodes must be biocompatible, biorobust and stable. In this work, the analysis and characterization of platinum (Pt) electrodes integrated on silicon substrates for biomedical applications are presented. Electrodes were incorporated on the surface of silicon chips by adhesion of laminated Pt foils or deposited at 30°, 45° or 90° angle by e-beam or physical vapor (sputtering) methods. Electrical and physical properties of the electrodes were quantified and evaluated using electrical impedance spectroscopy and modelling of the electrode-electrolyte interfaces. Electrode degradation in saline solution at pH7.4 was tested at room temperature and under accelerated conditions (90°C), both in the presence and absence of an applied electrical potential. Degradation was quantified using atomic force microscopy (AFM) and inductively coupled plasma mass spectroscopy (ICP-MS). Biocompatibility was assessed by MTT proliferation assay with human dermal fibroblasts. Results demonstrated that the deposited electrodes were biocompatible with negligible material degradation and exhibited electrochemical behavior similar to Pt foils, especially for e-beam deposited electrodes. Finally, Pt electrodes e-beam deposited on silicon nanofabricated nanochannel membranes were evaluated for controlled drug delivery applications. By tuning a low applied electrical potential (<1.5 VDC) to the electrodes, temporal modulation of the dendritic fullerene 1 (DF-1) release from a source reservoir was successfully achieved as a proof of concept, highlighting the potential of deposited electrodes in biomedical applications. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Implantable electrodes |2 nationallicence | |
| 690 | 7 | |a E-beam deposition |2 nationallicence | |
| 690 | 7 | |a Sputter deposition |2 nationallicence | |
| 690 | 7 | |a Nanochannel membranes |2 nationallicence | |
| 690 | 7 | |a Drug delivery |2 nationallicence | |
| 700 | 1 | |a Geninatti |D Thomas |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Bruno |D Giacomo |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Barile |D Bernardo |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Hood |D R. |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Farina |D Marco |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Schmulen |D Jeffrey |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 700 | 1 | |a Canavese |D Giancarlo |u IIT - Italian Institute of Technology, Center for Space Human Robotics, Corso Trento 21, 10129, Tutin, Italy |4 aut | |
| 700 | 1 | |a Grattoni |D Alessandro |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-11 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-014-9909-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-014-9909-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Geninatti |D Thomas |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bruno |D Giacomo |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Barile |D Bernardo |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hood |D R. |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Farina |D Marco |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schmulen |D Jeffrey |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Canavese |D Giancarlo |u IIT - Italian Institute of Technology, Center for Space Human Robotics, Corso Trento 21, 10129, Tutin, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Grattoni |D Alessandro |u Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, 77030, Houston, TX, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-11 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | ||