Controlled delivery of hollow corn protein nanoparticles via non-toxic crosslinking: in vivo and drug loading study
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| 024 | 7 | 0 | |a 10.1007/s10544-014-9926-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-014-9926-5 | ||
| 245 | 0 | 0 | |a Controlled delivery of hollow corn protein nanoparticles via non-toxic crosslinking: in vivo and drug loading study |h [Elektronische Daten] |c [Helan Xu, Li Shen, Lan Xu, Yiqi Yang] |
| 520 | 3 | |a In this research, controlled delivery of hollow nanoparticles from zein, the corn storage protein, to different organs of mice was achieved via crosslinking using citric acid, a non-toxic polycarboxylic acid derived from starch. Besides, crosslinking significantly enhanced water stability of nanoparticles while preserving their drug loading efficiency. Protein nanoparticles have been widely investigated as vehicles for delivery of therapeutics. However, protein nanoparticles were not stable in physiological conditions, easily cleared by mononuclear phagocyte system (MPS), and thus mainly accumulated and degraded in spleen and liver, the major MPS organs. Effective delivery to major non-MPS organs, such as kidney, was usually difficult to achieve, as well as long resident time of nanoparticles. In this research, hollow zein nanoparticles were chemically crosslinked with citric acid. Controlled delivery and prolonged accumulation of the nanoparticles in kidney, one major non-MPS organ, were achieved. The nanoparticles showed improved stability in aqueous environment at pH7.4 without affecting the adsorption of 5-FU, a common anticancer drug. In summary, citric acid crosslinked hollow zein nanoparticles could be potential vehicles for controllable delivery of anticancer therapeutics. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Corn protein |2 nationallicence | |
| 690 | 7 | |a Nanoparticles |2 nationallicence | |
| 690 | 7 | |a Non-toxic crosslinking |2 nationallicence | |
| 690 | 7 | |a Biodistribution |2 nationallicence | |
| 690 | 7 | |a Controlled delivery |2 nationallicence | |
| 700 | 1 | |a Xu |D Helan |u Department of Textiles, Merchandising and Fashion Design, 234, HECO Building, University of Nebraska-Lincoln, 68583-0802, Lincoln, NE, USA |4 aut | |
| 700 | 1 | |a Shen |D Li |u Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 201620, Shanghai, China |4 aut | |
| 700 | 1 | |a Xu |D Lan |u Department of Agronomy and Horticulture, University of Nebraska-Lincoln, 279, Plant Science Hall, 68583-0915, Lincoln, NE, USA |4 aut | |
| 700 | 1 | |a Yang |D Yiqi |u Department of Textiles, Merchandising and Fashion Design, 234, HECO Building, University of Nebraska-Lincoln, 68583-0802, Lincoln, NE, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-8 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-014-9926-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-014-9926-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Helan |u Department of Textiles, Merchandising and Fashion Design, 234, HECO Building, University of Nebraska-Lincoln, 68583-0802, Lincoln, NE, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shen |D Li |u Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 201620, Shanghai, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Lan |u Department of Agronomy and Horticulture, University of Nebraska-Lincoln, 279, Plant Science Hall, 68583-0915, Lincoln, NE, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D Yiqi |u Department of Textiles, Merchandising and Fashion Design, 234, HECO Building, University of Nebraska-Lincoln, 68583-0802, Lincoln, NE, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-8 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | ||