Multi-electrode array capable of supporting precisely patterned hippocampal neuronal networks
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| 003 | CHVBK | ||
| 005 | 20210128100410.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150201xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-014-9907-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-014-9907-8 | ||
| 245 | 0 | 0 | |a Multi-electrode array capable of supporting precisely patterned hippocampal neuronal networks |h [Elektronische Daten] |c [Tianyi Zhou, Susan Perry, Yevgeny Berdichevsky, Susanne Petryna, Vicki Fluck, Svetlana Tatic-Lucic] |
| 520 | 3 | |a Accurate positioning of primary mouse hippocampal neurons on electrodes enables the recording from and stimulation of specified individual neurons on a multi-electrode array (MEA). In this work, positive dielectrophoresis (DEP) is applied to actively recruit hippocampal neurons to the electrodes of a MEA, whereas microstructures such as chambers and trenches are created to effectively define a patterned neuronal network. We present here the effective pretreatment methods, to improve cytocompatibility of cured thin SU-8 epoxy, commonly used in the fabrication of MEAs. The functionality of our novel MEA is proven by the successful recording of spontaneous and stimulated neuronal potentials from primary hippocampal neurons, including the propagation of evoked neuronal bursts between electrodes. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Multi-electrode array (MEA) |2 nationallicence | |
| 690 | 7 | |a Dielectrophoresis (DEP) |2 nationallicence | |
| 690 | 7 | |a Precise patterning |2 nationallicence | |
| 690 | 7 | |a SU-8 cytocompatibility |2 nationallicence | |
| 690 | 7 | |a Hippocampal neuronal network |2 nationallicence | |
| 690 | 7 | |a Neuronal recording |2 nationallicence | |
| 700 | 1 | |a Zhou |D Tianyi |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 700 | 1 | |a Perry |D Susan |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 700 | 1 | |a Berdichevsky |D Yevgeny |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 700 | 1 | |a Petryna |D Susanne |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 700 | 1 | |a Fluck |D Vicki |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 700 | 1 | |a Tatic-Lucic |D Svetlana |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-12 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-014-9907-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-014-9907-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhou |D Tianyi |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Perry |D Susan |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Berdichevsky |D Yevgeny |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petryna |D Susanne |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fluck |D Vicki |u Bioengineering Program, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tatic-Lucic |D Svetlana |u Department of Electrical and Computer Engineering, Lehigh University, 18015, Bethlehem, PA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-12 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | ||