caa a22 4500 605479623 CHVBK 20210128100411.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10544-015-0009-z doi (NATIONALLICENCE)springer-10.1007/s10544-015-0009-z Electrical sensing of DNA-hybridization using two-port network based on suspended carbon nanotube membrane [Elektronische Daten] [Tun Wang, Ze-Zhi Zheng, Xing-Xing Feng, Hong Chen, Miao Lu] An approach was presented for electrical sensing of deoxyribonucleic acid (DNA)-hybridization in solution using a two-port network based on single-walled suspended carbon nanotube (SWCNT) membrane. A single stranded probe DNA (5′-NH2-(CH2)6-CGC CGA TTG GAC AAA ACT TAA A-3′) was immobilized on the SWCNT membrane. A solution with the complementary single stranded DNA (D′FITC: 5′-FITC-T TTA AGT TTT GTC CAA TCG GCG-3′) in various concentrations was then dropped on the membrane. The two-port network composed of the suspended SWCNT membrane and its underneath gate were characterized by coupling with a vector network analyzer. The resonance frequency of transmission coefficient S21 was observed to be around 10MHz. The resonance frequency shifts with DNA-hybridization, and the sensing limit was approximately 50 nM. The advantages of this approach include low-noise frequency output, solution based real time detection and capable of on-chip integration, etc. Springer Science+Business Media New York, 2015 DNA detection nationallicence Suspended carbon nanotube membrane nationallicence Two-port network nationallicence Wang Tun Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut Zheng Ze-Zhi Department of Physics, Xiamen University, 361005, Xiamen, China aut Feng Xing-Xing Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut Chen Hong Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut Lu Miao Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/6(2015-12-01), 1-7 1387-2176 17:6<1 2015 17 10544 https://doi.org/10.1007/s10544-015-0009-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-0009-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Tun Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Zheng Ze-Zhi Department of Physics, Xiamen University, 361005, Xiamen, China aut NATIONALLICENCE 700 1- Feng Xing-Xing Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Chen Hong Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Lu Miao Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, 361005, Xiamen, People's Republic of China aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/6(2015-12-01), 1-7 1387-2176 17:6<1 2015 17 10544