Untethered magnetic millirobot for targeted drug delivery
| LEADER | caa a22 4500 | ||
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| 001 | 605479739 | ||
| 003 | CHVBK | ||
| 005 | 20210128100411.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150601xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-015-9962-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-015-9962-9 | ||
| 245 | 0 | 0 | |a Untethered magnetic millirobot for targeted drug delivery |h [Elektronische Daten] |c [Veronica Iacovacci, Gioia Lucarini, Leonardo Ricotti, Paolo Dario, Pierre Dupont, Arianna Menciassi] |
| 520 | 3 | |a This paper reports the design and development of a novel millimeter-sized robotic system for targeted therapy. The proposed medical robot is conceived to perform therapy in relatively small diameter body canals (spine, urinary system, ovary, etc.), and to release several kinds of therapeutics, depending on the pathology to be treated. The robot is a nearly-buoyant bi-component system consisting of a carrier, in which the therapeutic agent is embedded, and a piston. The piston, by exploiting magnetic effects, docks with the carrier and compresses a drug-loaded hydrogel, thus activating the release mechanism. External magnetic fields are exploited to propel the robot towards the target region, while intermagnetic forces are exploited to trigger drug release. After designing and fabricating the robot, the system has been tested in vitro with an anticancer drug (doxorubicin) embedded in the carrier. The efficiency of the drug release mechanism has been demonstrated by both quantifying the amount of drug released and by assessing the efficacy of this therapeutic procedure on human bladder cancer cells. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Drug delivery system |2 nationallicence | |
| 690 | 7 | |a Drug-loaded hydrogel |2 nationallicence | |
| 690 | 7 | |a Magnetic robot |2 nationallicence | |
| 690 | 7 | |a Magnetic docking |2 nationallicence | |
| 690 | 7 | |a Microrobotics |2 nationallicence | |
| 690 | 7 | |a Targeted therapy |2 nationallicence | |
| 700 | 1 | |a Iacovacci |D Veronica |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | |
| 700 | 1 | |a Lucarini |D Gioia |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | |
| 700 | 1 | |a Ricotti |D Leonardo |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | |
| 700 | 1 | |a Dario |D Paolo |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | |
| 700 | 1 | |a Dupont |D Pierre |u Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 02115, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Menciassi |D Arianna |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/3(2015-06-01), 1-12 |x 1387-2176 |q 17:3<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-015-9962-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-015-9962-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iacovacci |D Veronica |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lucarini |D Gioia |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ricotti |D Leonardo |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dario |D Paolo |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dupont |D Pierre |u Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 02115, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Menciassi |D Arianna |u The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/3(2015-06-01), 1-12 |x 1387-2176 |q 17:3<1 |1 2015 |2 17 |o 10544 | ||