caa a22 4500 605479739 CHVBK 20210128100411.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10544-015-9962-9 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9962-9 Untethered magnetic millirobot for targeted drug delivery [Elektronische Daten] [Veronica Iacovacci, Gioia Lucarini, Leonardo Ricotti, Paolo Dario, Pierre Dupont, Arianna Menciassi] This paper reports the design and development of a novel millimeter-sized robotic system for targeted therapy. The proposed medical robot is conceived to perform therapy in relatively small diameter body canals (spine, urinary system, ovary, etc.), and to release several kinds of therapeutics, depending on the pathology to be treated. The robot is a nearly-buoyant bi-component system consisting of a carrier, in which the therapeutic agent is embedded, and a piston. The piston, by exploiting magnetic effects, docks with the carrier and compresses a drug-loaded hydrogel, thus activating the release mechanism. External magnetic fields are exploited to propel the robot towards the target region, while intermagnetic forces are exploited to trigger drug release. After designing and fabricating the robot, the system has been tested in vitro with an anticancer drug (doxorubicin) embedded in the carrier. The efficiency of the drug release mechanism has been demonstrated by both quantifying the amount of drug released and by assessing the efficacy of this therapeutic procedure on human bladder cancer cells. Springer Science+Business Media New York, 2015 Drug delivery system nationallicence Drug-loaded hydrogel nationallicence Magnetic robot nationallicence Magnetic docking nationallicence Microrobotics nationallicence Targeted therapy nationallicence Iacovacci Veronica The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut Lucarini Gioia The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut Ricotti Leonardo The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut Dario Paolo The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut Dupont Pierre Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 02115, Boston, MA, USA aut Menciassi Arianna The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-12 1387-2176 17:3<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9962-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9962-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iacovacci Veronica The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut NATIONALLICENCE 700 1- Lucarini Gioia The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut NATIONALLICENCE 700 1- Ricotti Leonardo The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut NATIONALLICENCE 700 1- Dario Paolo The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut NATIONALLICENCE 700 1- Dupont Pierre Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Menciassi Arianna The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio, 34, 56025, Pontedera, Pisa, Italy aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-12 1387-2176 17:3<1 2015 17 10544