caa a22 4500 605479763 CHVBK 20210128100411.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10544-015-9961-x doi (NATIONALLICENCE)springer-10.1007/s10544-015-9961-x Fabrication and initial testing of the μDBS: a novel Deep Brain Stimulation electrode with thousands of individually controllable contacts [Elektronische Daten] [Andrew Willsie, Alan Dorval] High frequency electrical stimulation of deep brain structures such as the subthalamic nucleus in Parkinson's disease or thalamus for essential tremor is used clinically to reduce symptom severity. Deep brain stimulation activates neurons in specific brain structures and connection pathways, overriding aberrant neural activity associated with symptoms. While optimal deep brain stimulation might activate a particular neural structure precisely, existing deep brain stimulation can only generate roughly-spherical regions of activation that do not overlap with any target anatomy. Additionally, side effects linked to stimulation may be the result of limited control over placement of stimulation and its subsequent spread out of optimal target boundaries. We propose a novel lead with thousands of individually controllable contacts capable of asymmetric stimulation profiles. Here we outline the design motivation, manufacturing process, and initial testing of this new electrode design, placing it on track for further directional stimulation studies. Springer Science+Business Media New York, 2015 Deep brain stimulation nationallicence Current steering nationallicence Microelectrode array nationallicence Parkinson's disease nationallicence Willsie Andrew University of Utah, 84112, Salt Lake City, UT, USA aut Dorval Alan University of Utah, 84112, Salt Lake City, UT, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-12 1387-2176 17:3<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9961-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9961-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willsie Andrew University of Utah, 84112, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Dorval Alan University of Utah, 84112, Salt Lake City, UT, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-12 1387-2176 17:3<1 2015 17 10544