caa a22 4500 605479771 CHVBK 20210128100411.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10544-015-9953-x doi (NATIONALLICENCE)springer-10.1007/s10544-015-9953-x Cellular aggregate capture by fluidic manipulation device highly compatible with micro-well-plates [Elektronische Daten] [Satoshi Konishi, Yumi Teramachi, Shuhei Shimomura, Wataru Tonomura, Shuhei Tajima, Yasuhiko Tabata] This paper proposes a capture device to manipulate and transport a cellular aggregate in a micro-well. A cellular aggregate (a few hundreds μm in diameter) is currently manipulated by a pipette. The manual manipulation by a pipette has problems; low reliability, low throughput, and difficulty in confirmation of task completion. We took into account of compatibility with existing methods such as a micro-well-plate and designed for the capture device of a cellular aggregate in a micro-well. A newly developed capture device flows and carries a cellular aggregate from a bottom of a well to a trap of the capture device. We designed a curved surface at the bottom of the capture device to form a space to act as a channel between the inner wall of the micro-well. This paper presents concept, design, fabrication, and of the proposed cellular aggregate capture, followed by successful experimental results. Springer Science+Business Media New York, 2015 Cellular aggregate nationallicence uTAS nationallicence Capture nationallicence Fluidic manipulation nationallicence Micro-well-plate nationallicence Konishi Satoshi Department of Mechanical Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut Teramachi Yumi Graduate School of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut Shimomura Shuhei Graduate School of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut Tonomura Wataru Department of Mechanical Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut Tajima Shuhei Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan aut Tabata Yasuhiko Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-6 1387-2176 17:3<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9953-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9953-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Konishi Satoshi Department of Mechanical Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut NATIONALLICENCE 700 1- Teramachi Yumi Graduate School of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut NATIONALLICENCE 700 1- Shimomura Shuhei Graduate School of Science and Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut NATIONALLICENCE 700 1- Tonomura Wataru Department of Mechanical Engineering, Ritsumeikan University, 1-1-1 Noji-higashi, 525-8577, Kusatsu, Shiga, Japan aut NATIONALLICENCE 700 1- Tajima Shuhei Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 700 1- Tabata Yasuhiko Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/3(2015-06-01), 1-6 1387-2176 17:3<1 2015 17 10544