pH-triggered drug release from biodegradable microwells for oral drug delivery
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| 005 | 20210128100412.0 | ||
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| 008 | 210128e20150601xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-015-9958-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-015-9958-5 | ||
| 245 | 0 | 0 | |a pH-triggered drug release from biodegradable microwells for oral drug delivery |h [Elektronische Daten] |c [Line Nielsen, Johan Nagstrup, Sarah Gordon, Stephan Keller, Jesper Østergaard, Thomas Rades, Anette Müllertz, Anja Boisen] |
| 520 | 3 | |a Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240μm and a height of 100μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH1.6) was employed, after which a change to biorelevant intestinal release medium (pH6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Biodegradable polymer |2 nationallicence | |
| 690 | 7 | |a Oral drug delivery |2 nationallicence | |
| 690 | 7 | |a Micro delivery systems |2 nationallicence | |
| 690 | 7 | |a Furosemide |2 nationallicence | |
| 690 | 7 | |a μ-Diss profiler |2 nationallicence | |
| 690 | 7 | |a UV imaging |2 nationallicence | |
| 700 | 1 | |a Nielsen |D Line |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | |
| 700 | 1 | |a Nagstrup |D Johan |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | |
| 700 | 1 | |a Gordon |D Sarah |u Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Saarbrücken, Germany |4 aut | |
| 700 | 1 | |a Keller |D Stephan |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | |
| 700 | 1 | |a Østergaard |D Jesper |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | |
| 700 | 1 | |a Rades |D Thomas |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | |
| 700 | 1 | |a Müllertz |D Anette |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | |
| 700 | 1 | |a Boisen |D Anja |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/3(2015-06-01), 1-7 |x 1387-2176 |q 17:3<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-015-9958-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-015-9958-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nielsen |D Line |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagstrup |D Johan |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gordon |D Sarah |u Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Saarbrücken, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Keller |D Stephan |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Østergaard |D Jesper |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rades |D Thomas |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Müllertz |D Anette |u Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boisen |D Anja |u Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345B, Kongens Lyngby, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/3(2015-06-01), 1-7 |x 1387-2176 |q 17:3<1 |1 2015 |2 17 |o 10544 | ||