caa a22 4500 605479879 CHVBK 20210128100412.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9972-7 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9972-7 A bio-inspired attachment mechanism for long-term adhesion to the small intestine [Elektronische Daten] [Wanchuan Xie, Vishal Kothari, Benjamin Terry] To achieve long-term attachment of capsule endoscopes (CEs) and miniature biosensors in the human gastrointestinal (GI) tract, a tissue attachment mechanism (TAM) was designed, optimized and tested for safety and adhesive capabilities on excised tissue in vitro and in vivo on a live pig model. Six TAMs were tested for their attachment strength in an in vitro attachment tensile experiment in which each TAM was tested on three different proximal intestine tissue samples. The maximum strength and average value are 8.09N and 4.54N respectively. The initial attachment damage was tested for 10min using a sine wave pull force on the TAM with a 0.4N peak value and 6s period, which represents typical human intestinal traction force from peristalsis. The in vitro attachment tensile test verified that the tissue was not visually damaged nor perforated by the attachment process. In the in vivo experiment, four TAMs were placed in the intestine of a pig through individual longitudinal enterotomies. X-ray images were taken each hour after the surgery and showed zero migration of the TAMs after 24h of adhesion. X-ray images taken each day indicated the attachment duration of this mechanism lasted up to 6days. Post experiment inspection confirmed the attachment did not cause visible damage to tissue. These results confirmed the reliability of the TAM in vivo and demonstrated preliminary feasibility of long-term sensor adhesion to the GI tract. Springer Science+Business Media New York, 2015 Capsule endoscopy nationallicence Intestinal adhesion nationallicence Attachment mechanism nationallicence Xie Wanchuan Department of Mechanical and Materials Engineering, 360 Walter Scott Engineering Center, University of Nebraska-Lincoln, 68508, Lincoln, NE, USA aut Kothari Vishal Department of Surgery, Nebraska Medicine - Bariatrics Center, University of Nebraska Medical Center, 4400 Emile Street, 68198, Omaha, NE, USA aut Terry Benjamin Department of Mechanical and Materials Engineering, 360 Walter Scott Engineering Center, University of Nebraska-Lincoln, 68508, Lincoln, NE, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-9 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9972-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9972-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xie Wanchuan Department of Mechanical and Materials Engineering, 360 Walter Scott Engineering Center, University of Nebraska-Lincoln, 68508, Lincoln, NE, USA aut NATIONALLICENCE 700 1- Kothari Vishal Department of Surgery, Nebraska Medicine - Bariatrics Center, University of Nebraska Medical Center, 4400 Emile Street, 68198, Omaha, NE, USA aut NATIONALLICENCE 700 1- Terry Benjamin Department of Mechanical and Materials Engineering, 360 Walter Scott Engineering Center, University of Nebraska-Lincoln, 68508, Lincoln, NE, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-9 1387-2176 17:4<1 2015 17 10544