caa a22 4500 605479887 CHVBK 20210128100412.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9986-1 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9986-1 Effect of TiO2 nanotubes arrays on osseointegration of orthodontic miniscrew [Elektronische Daten] [Insan Jang, Seong-Cheol Shim, Dong-Soon Choi, Bong-Kuen Cha, Jae-Kwan Lee, Byung-Hak Choe, Won-Youl Choi] To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO2 nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO2 nanotube arrays. The diameter and length of the TiO2 nanotube arrays were ~ 70nm and ~ 5μm, respectively. The miniscrews with TiO2 nanotube arrays were implanted in the legs of New Zealand white rabbits for 8weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO2 nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8% than the control, 29.3%. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO2 nanotube arrays, at 81.2% than those in the control via micro-CT analysis. Our findings support that TiO2 nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew. Springer Science+Business Media New York, 2015 Nanotubes nationallicence Orthodontic anchorage nationallicence Osseointegration nationallicence Bone volume nationallicence micro-CT nationallicence Jang Insan Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Shim Seong-Cheol Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Choi Dong-Soon Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Cha Bong-Kuen Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Lee Jae-Kwan Department of Periodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Choe Byung-Hak Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Choi Won-Youl Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-7 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9986-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9986-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jang Insan Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Shim Seong-Cheol Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Choi Dong-Soon Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Cha Bong-Kuen Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Lee Jae-Kwan Department of Periodontics, College of Dentistry, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Choe Byung-Hak Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 700 1- Choi Won-Youl Department of Metal and Materials Engineering, Gangneung-Wonju National University, 210-720, Gangneung, South Korea aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-7 1387-2176 17:4<1 2015 17 10544