caa a22 4500 605479909 CHVBK 20210128100412.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9978-1 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9978-1 Microtubule guiding in a multi-walled carbon nanotube circuit [Elektronische Daten] [Aurélien Sikora, Javier Ramón-Azcón, Mustafa Sen, Kyongwan Kim, Hikaru Nakazawa, Mitsuo Umetsu, Izumi Kumagai, Hitoshi Shiku, Tomokazu Matsue, Winfried Teizer] In nanotechnological devices, mass transport can be initiated by pressure driven flow, diffusion or by employing molecular motors. As the scale decreases, molecular motors can be helpful as they are not limited by increased viscous resistance. Moreover, molecular motors can move against diffusion gradients and are naturally fitted for nanoscale transportation. Among motor proteins, kinesin has particular potential for lab-on-a-chip applications. It can be used for sorting, concentrating or as a mechanical sensor. When bound to a surface, kinesin motors propel microtubules in random directions, depending on their landing orientation. In order to circumvent this complication, the microtubule motion should be confined or guided. To this end, dielectrophoretically aligned multi-walled-carbon nanotubes (MWCNT) can be employed as nanotracks. In order to control more precisely the spatial repartition of the MWCNTs, a screening method has been implemented and tested. Polygonal patterns have been fabricated with the aim of studying the guiding and the microtubule displacement between MWCNT segments. Microtubules are observed to transfer between MWCNT segments, a prerequisite for the guiding of microtubules in MWCNT circuit-based biodevices. The effect of the MWCNT organization (crenellated or hexagonal) on the MT travel distance has been investigated as well. Springer Science+Business Media New York, 2015 Carbon nationallicence Nanotube nationallicence Microtubule nationallicence Kinesin nationallicence Dielectrophoresis nationallicence Sikora Aurélien WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut Ramón-Azcón Javier Department of Chemical and Biomolecular Nanotechnology, Advanced Chemical Research Institute of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034, Barcelona, Spain aut Sen Mustafa Graduate School of Environmental Studies, Tohoku University, 980-8579, Sendai, Japan aut Kim Kyongwan WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut Nakazawa Hikaru Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut Umetsu Mitsuo Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut Kumagai Izumi Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut Shiku Hitoshi WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut Matsue Tomokazu WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut Teizer Winfried WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-6 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9978-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9978-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sikora Aurélien WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut NATIONALLICENCE 700 1- Ramón-Azcón Javier Department of Chemical and Biomolecular Nanotechnology, Advanced Chemical Research Institute of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034, Barcelona, Spain aut NATIONALLICENCE 700 1- Sen Mustafa Graduate School of Environmental Studies, Tohoku University, 980-8579, Sendai, Japan aut NATIONALLICENCE 700 1- Kim Kyongwan WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut NATIONALLICENCE 700 1- Nakazawa Hikaru Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut NATIONALLICENCE 700 1- Umetsu Mitsuo Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut NATIONALLICENCE 700 1- Kumagai Izumi Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan aut NATIONALLICENCE 700 1- Shiku Hitoshi WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut NATIONALLICENCE 700 1- Matsue Tomokazu WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut NATIONALLICENCE 700 1- Teizer Winfried WPI Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, 980-8577, Sendai, Japan aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-6 1387-2176 17:4<1 2015 17 10544