Testicular biodistribution of silica-gold nanoparticles after intramuscular injection in mice
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| 024 | 7 | 0 | |a 10.1007/s10544-015-9968-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-015-9968-3 | ||
| 245 | 0 | 0 | |a Testicular biodistribution of silica-gold nanoparticles after intramuscular injection in mice |h [Elektronische Daten] |c [Lara Leclerc, Jean-Philippe Klein, Valérie Forest, Delphine Boudard, Matteo Martini, Jérémie Pourchez, Marie-Geneviève Blanchin, Michèle Cottier] |
| 520 | 3 | |a With the continuing development of nanomaterials, the assessment of their potential impact on human health, and especially human reproductive toxicity, is a major issue. The testicular biodistribution of nanoparticles remains poorly studied. This study investigated whether gold-silica nanoparticles could be detected in mouse testes after intramuscular injection, with a particular focus on their ability to cross the blood-testis barrier. To that purpose, well-characterized 70-nm gold core-silica shell nanoparticles were used to ensure sensitive detection using high-resolution techniques. Testes were collected at different time points corresponding to spermatogenesis stages in mice. Transmission electron microscopy and confocal microscopy were used for nanoparticle detection, and nanoparticle quantification was performed by atomic emission spectroscopy. All these techniques showed that no particles were able to reach the testes. Results accorded with the normal histological appearance of testes even at 45days post sacrifice. High-resolution techniques did not detect 70-nm silica-gold nanoparticles in mouse testes after intramuscular injection. These results are reassuring about the safety of nanoparticles with regard to male human reproduction, especially in the context of nanomedicine. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Nanoparticles |2 nationallicence | |
| 690 | 7 | |a Mice |2 nationallicence | |
| 690 | 7 | |a Testes |2 nationallicence | |
| 690 | 7 | |a Intramuscular injection |2 nationallicence | |
| 690 | 7 | |a Reproductive toxicity |2 nationallicence | |
| 700 | 1 | |a Leclerc |D Lara |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 700 | 1 | |a Klein |D Jean-Philippe |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 700 | 1 | |a Forest |D Valérie |u Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 700 | 1 | |a Boudard |D Delphine |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 700 | 1 | |a Martini |D Matteo |u Institut Lumière Matière, UMR 5306 Université Claude Bernard Lyon1 - CNRS, Université de Lyon, 69622, Villeurbanne cedex, France |4 aut | |
| 700 | 1 | |a Pourchez |D Jérémie |u Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 700 | 1 | |a Blanchin |D Marie-Geneviève |u Institut Lumière Matière, UMR 5306 Université Claude Bernard Lyon1 - CNRS, Université de Lyon, 69622, Villeurbanne cedex, France |4 aut | |
| 700 | 1 | |a Cottier |D Michèle |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/4(2015-08-01), 1-11 |x 1387-2176 |q 17:4<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-015-9968-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-015-9968-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leclerc |D Lara |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Klein |D Jean-Philippe |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Forest |D Valérie |u Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boudard |D Delphine |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Martini |D Matteo |u Institut Lumière Matière, UMR 5306 Université Claude Bernard Lyon1 - CNRS, Université de Lyon, 69622, Villeurbanne cedex, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pourchez |D Jérémie |u Ecole Nationale Supérieure des Mines, CIS-EMSE, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Blanchin |D Marie-Geneviève |u Institut Lumière Matière, UMR 5306 Université Claude Bernard Lyon1 - CNRS, Université de Lyon, 69622, Villeurbanne cedex, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cottier |D Michèle |u University of Lyon, Jean Monnet University, EA 4624 - LINA, SFR FED 4166 - IFRESIS, 42023, Saint-Etienne, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/4(2015-08-01), 1-11 |x 1387-2176 |q 17:4<1 |1 2015 |2 17 |o 10544 | ||