caa a22 4500 605479968 CHVBK 20210128100412.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9984-3 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9984-3 New multimodal data obtained in-vivo from a single ultra-miniature transducer [Elektronische Daten] [Therese Clark, Simon Malpas, Daniel McCormick, Sarah-Jane Guild, David Budgett] Recent advances in multimodal sensing technology and sensor miniaturization technologies are paving the way for a new era in physiological measurement. Traditional approaches have integrated several transducers on a single silicon chip or packaged several sensing elements within a biocompatible catheter. Thermal and electrical cross-talk between sensors, time-lag between parallel measurements, lower yields associated with the increased complexity, and restrictions on the minimum size are challenges presented by these approaches. We present an alternative method which enables simultaneous measurement of temperature, pressure and heart rate to be obtained from a single ultra-miniature solid-state transducer. For the first time multimodal data were obtained from the sensor located within the abdominal aortas of five rats. The catheter-tip sensor interfaces with a fully implanted and inductively powered telemetry device capable of operating for the lifetime of the animal. Results of this study demonstrate good agreement between the core-temperature measurement from the catheter-tip sensor and the reference sensor with mean difference between the two sensors of 0.03°C ± 0.02°C (n = 5, 7days). Real-time data obtained in the undisturbed rat, revealed fluctuations associated with the rest-activity cycle, in temperature, mean arterial pressure and heart rate. The stress response was shown to elicit an elevation in the core temperature of 1.5°C. This was heralded by an elevation in mean arterial pressure of 35mmHg and heart rate of 160bpm. Obtaining multiple parameters from a single transducer goes a considerable way towards overcoming challenges of the prior art. Springer Science+Business Media New York, 2015 Multimodal nationallicence Microsensors nationallicence Multiparameter sensors nationallicence Piezoresistive devices nationallicence Pressure measurement nationallicence Semiconductor devices nationallicence Temperature measurement nationallicence Thermoresistivity nationallicence Telemetry nationallicence Implantable devices nationallicence Clark Therese Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut Malpas Simon Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut McCormick Daniel Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut Guild Sarah-Jane Department of Physiology, University of Auckland, Auckland, New Zealand aut Budgett David Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-11 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9984-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9984-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clark Therese Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Malpas Simon Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- McCormick Daniel Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Guild Sarah-Jane Department of Physiology, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Budgett David Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-11 1387-2176 17:4<1 2015 17 10544