caa a22 4500 605479984 CHVBK 20210128100412.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9980-7 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9980-7 Wireless programmable electrochemical drug delivery micropump with fully integrated electrochemical dosing sensors [Elektronische Daten] [Roya Sheybani, Angelica Cobo, Ellis Meng] We present a fully integrated implantable electrolysis-based micropump with incorporated EI dosing sensors. Wireless powering and data telemetry (through amplitude and frequency modulation) were utilized to achieve variable flow control and a bi-directional data link with the sensors. Wireless infusion rate control (0.14-1.04μL/min) and dose sensing (bolus resolution of 0.55-2μL) were each calibrated separately with the final circuit architecture and then simultaneous wireless flow control and dose sensing were demonstrated. Recombination detection using the dosing system, as well as, effects of coil separation distance and misalignment in wireless power and data transfer were studied. A custom-made normally closed spring-loaded ball check valve was designed and incorporated at the reservoir outlet to prevent backflow of fluids as a result of the reverse pressure gradient caused by recombination of electrolysis gases. Successful delivery, infusion rate control, and dose sensing were achieved in simulated brain tissue. Springer Science+Business Media New York, 2015 Electrolysis micropump nationallicence Electrochemical sensors nationallicence Patient-tailored drug delivery nationallicence Dosing accuracy nationallicence Check valve nationallicence Sheybani Roya Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut Cobo Angelica Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut Meng Ellis Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-13 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9980-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9980-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheybani Roya Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Cobo Angelica Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Meng Ellis Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, 90089-1111, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-13 1387-2176 17:4<1 2015 17 10544