caa a22 4500 605480001 CHVBK 20210128100413.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10544-015-9976-3 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9976-3 Predicting and managing heat dissipation from a neural probe [Elektronische Daten] [Andrew Smith, Matthew Christian, Samara Firebaugh, Garret Cooper, Brian Jamieson] Light stimulating neural probes are rapidly increasing our understanding of neural pathways. Relocating the externally coupled light source to the probe tip has the potential to dramatically improve the flexibility of the technique. However, this approach would generate heat within the embedded probe where even minor temperature excursions could easily damage tissues under study. A COMSOL model was used to study the thermal effects of these heated probes in the brain including blood perfusion and metabolic heating, and to investigate the effect of passive methods for improving heat dissipation. The probe temperature initially decreases with insertion depth, and then becomes steady. Extending the probe beyond the heated region has a similar effect, while increasing the size of the heated region steadily decreases the probe temperature. Increasing the thermal conductivity of the probe promotes spreading, decreasing the probe temperature. The effects of insertion depth and probe power dissipation were experimentally tested with a microfabricated, heated mock neural probe. The heated probe was tested in 0.65% agarose gel at room temperature and in ex vivo cow brain at body temperature. The thermal resistance between the probe and the neural tissue or agarose gel was determined at a range of insertion depths and compared to the COMSOL model. © Springer Science+Business Media New York (outside the USA), 2015 Neural probe thermal management nationallicence Heated neural probe nationallicence Neuron photostimulation nationallicence Bioheat equation nationallicence Heat transfer in neural tissue nationallicence Smith Andrew Department of Mechanical Engineering, U.S. Naval Academy, 21402, Annapolis, MD, USA aut Christian Matthew Department of Mechanical Engineering, U.S. Naval Academy, 21402, Annapolis, MD, USA aut Firebaugh Samara Department of Electrical and Computer Engineering, U.S. Naval Academy, Annapolis, MD, USA aut Cooper Garret SB Microsystems, Columbia, MD, USA aut Jamieson Brian SB Microsystems, Columbia, MD, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-9 1387-2176 17:4<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9976-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9976-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smith Andrew Department of Mechanical Engineering, U.S. Naval Academy, 21402, Annapolis, MD, USA aut NATIONALLICENCE 700 1- Christian Matthew Department of Mechanical Engineering, U.S. Naval Academy, 21402, Annapolis, MD, USA aut NATIONALLICENCE 700 1- Firebaugh Samara Department of Electrical and Computer Engineering, U.S. Naval Academy, Annapolis, MD, USA aut NATIONALLICENCE 700 1- Cooper Garret SB Microsystems, Columbia, MD, USA aut NATIONALLICENCE 700 1- Jamieson Brian SB Microsystems, Columbia, MD, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/4(2015-08-01), 1-9 1387-2176 17:4<1 2015 17 10544