Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow
| LEADER | caa a22 4500 | ||
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| 001 | 605480036 | ||
| 003 | CHVBK | ||
| 005 | 20210128100413.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-015-9992-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-015-9992-3 | ||
| 245 | 0 | 0 | |a Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow |h [Elektronische Daten] |c [Chunyan Li, Pei-ming Wu, Zhizhen Wu, Kanokwan Limnuson, Neal Mehan, Cameron Mozayan, Eugene Golanov, Chong Ahn, Jed Hartings, Raj Narayan] |
| 520 | 3 | |a Cerebral blood flow (CBF) plays a critical role in the exchange of nutrients and metabolites at the capillary level and is tightly regulated to meet the metabolic demands of the brain. After major brain injuries, CBF normally decreases and supporting the injured brain with adequate CBF is a mainstay of therapy after traumatic brain injury. Quantitative and localized measurement of CBF is therefore critically important for evaluation of treatment efficacy and also for understanding of cerebral pathophysiology. We present here an improved thermal flow microsensor and its operation which provides higher accuracy compared to existing devices. The flow microsensor consists of three components, two stacked-up thin film resistive elements serving as composite heater/temperature sensor and one remote resistive element for environmental temperature compensation. It operates in constant-temperature mode (~2°C above the medium temperature) providing 20ms temporal resolution. Compared to previous thermal flow microsensor based on self-heating and self-sensing design, the sensor presented provides at least two-fold improvement in accuracy in the range from 0 to 200ml/100g/min. This is mainly achieved by using the stacked-up structure, where the heating and sensing are separated to improve the temperature measurement accuracy by minimization of errors introduced by self-heating. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Thermal flow microsensor |2 nationallicence | |
| 690 | 7 | |a Cerebral blood flow |2 nationallicence | |
| 690 | 7 | |a Thin-film resistive element |2 nationallicence | |
| 690 | 7 | |a Self-heating error |2 nationallicence | |
| 700 | 1 | |a Li |D Chunyan |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | |
| 700 | 1 | |a Wu |D Pei-ming |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | |
| 700 | 1 | |a Wu |D Zhizhen |u Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA |4 aut | |
| 700 | 1 | |a Limnuson |D Kanokwan |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | |
| 700 | 1 | |a Mehan |D Neal |u Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA |4 aut | |
| 700 | 1 | |a Mozayan |D Cameron |u Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA |4 aut | |
| 700 | 1 | |a Golanov |D Eugene |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | |
| 700 | 1 | |a Ahn |D Chong |u Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA |4 aut | |
| 700 | 1 | |a Hartings |D Jed |u Department of Neurosurgery, UC College of Medicine, University of Cincinnati (UC) Neuroscience Institute, 45219, Cincinnati, OH, USA |4 aut | |
| 700 | 1 | |a Narayan |D Raj |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/5(2015-10-01), 1-7 |x 1387-2176 |q 17:5<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-015-9992-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-015-9992-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Chunyan |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Pei-ming |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Zhizhen |u Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Limnuson |D Kanokwan |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mehan |D Neal |u Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mozayan |D Cameron |u Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Golanov |D Eugene |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ahn |D Chong |u Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hartings |D Jed |u Department of Neurosurgery, UC College of Medicine, University of Cincinnati (UC) Neuroscience Institute, 45219, Cincinnati, OH, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Narayan |D Raj |u Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/5(2015-10-01), 1-7 |x 1387-2176 |q 17:5<1 |1 2015 |2 17 |o 10544 | ||