caa a22 4500 605480036 CHVBK 20210128100413.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10544-015-9992-3 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9992-3 Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow [Elektronische Daten] [Chunyan Li, Pei-ming Wu, Zhizhen Wu, Kanokwan Limnuson, Neal Mehan, Cameron Mozayan, Eugene Golanov, Chong Ahn, Jed Hartings, Raj Narayan] Cerebral blood flow (CBF) plays a critical role in the exchange of nutrients and metabolites at the capillary level and is tightly regulated to meet the metabolic demands of the brain. After major brain injuries, CBF normally decreases and supporting the injured brain with adequate CBF is a mainstay of therapy after traumatic brain injury. Quantitative and localized measurement of CBF is therefore critically important for evaluation of treatment efficacy and also for understanding of cerebral pathophysiology. We present here an improved thermal flow microsensor and its operation which provides higher accuracy compared to existing devices. The flow microsensor consists of three components, two stacked-up thin film resistive elements serving as composite heater/temperature sensor and one remote resistive element for environmental temperature compensation. It operates in constant-temperature mode (~2°C above the medium temperature) providing 20ms temporal resolution. Compared to previous thermal flow microsensor based on self-heating and self-sensing design, the sensor presented provides at least two-fold improvement in accuracy in the range from 0 to 200ml/100g/min. This is mainly achieved by using the stacked-up structure, where the heating and sensing are separated to improve the temperature measurement accuracy by minimization of errors introduced by self-heating. Springer Science+Business Media New York, 2015 Thermal flow microsensor nationallicence Cerebral blood flow nationallicence Thin-film resistive element nationallicence Self-heating error nationallicence Li Chunyan Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut Wu Pei-ming Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut Wu Zhizhen Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA aut Limnuson Kanokwan Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut Mehan Neal Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA aut Mozayan Cameron Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA aut Golanov Eugene Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut Ahn Chong Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA aut Hartings Jed Department of Neurosurgery, UC College of Medicine, University of Cincinnati (UC) Neuroscience Institute, 45219, Cincinnati, OH, USA aut Narayan Raj Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-7 1387-2176 17:5<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9992-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9992-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Chunyan Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Wu Pei-ming Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Wu Zhizhen Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Limnuson Kanokwan Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Mehan Neal Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA aut NATIONALLICENCE 700 1- Mozayan Cameron Department of Neurosurgery, Hofstra North Shore-LIJ School of Medicine, 11549, Hempstead, NY, USA aut NATIONALLICENCE 700 1- Golanov Eugene Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Ahn Chong Microsystem and BioMEMS Laboratory, University of Cincinnati, 45221, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Hartings Jed Department of Neurosurgery, UC College of Medicine, University of Cincinnati (UC) Neuroscience Institute, 45219, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Narayan Raj Cushing Neuromonitoring Laboratory, Feinstein Institute for Medical Research, 11030, Manhasset, NY, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-7 1387-2176 17:5<1 2015 17 10544