caa a22 4500 605480087 CHVBK 20210128100413.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10544-015-9985-2 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9985-2 A nanopore membrane regulator device for laser modulated flow after glaucoma surgery [Elektronische Daten] [Jeffrey Olson, Ramanath Bhandari, Sergio Groman-Lupa, Raul Velez-Montoya] Glaucoma, the second most common cause of blindness in the world, is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. Filtration surgery is one of the most effective means to significantly lower IOP compared to medical or laser treatments, and it is typically reserved for advanced disease. However, there are high rates of postoperative complications associated with the procedure, often from over- or under-filtration. To address these problems, the glaucoma drainage device regulator (GDDR) implant was developed to allow post-operative control of aqueous flow and IOP. The device, a tube with a nanopore membrane, is placed beneath the scleral flap. Postoperatively, the membrane surface can be ruptured with a laser to augment flow through the system. This feature allows adjustable control of aqueous flow and diminishes the risk of hypotony in the early postoperative period. Springer Science+Business Media New York, 2015 Glaucoma drainage device nationallicence Intraocular pressure nationallicence Aqueous flow nationallicence Olson Jeffrey Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut Bhandari Ramanath Department of Ophthalmology, Springfield Clinic, Springfield, IL, USA aut Groman-Lupa Sergio Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut Velez-Montoya Raul Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-6 1387-2176 17:5<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9985-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9985-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olson Jeffrey Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Bhandari Ramanath Department of Ophthalmology, Springfield Clinic, Springfield, IL, USA aut NATIONALLICENCE 700 1- Groman-Lupa Sergio Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Velez-Montoya Raul Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Court, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-6 1387-2176 17:5<1 2015 17 10544