caa a22 4500 605480095 CHVBK 20210128100413.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10544-015-9999-9 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9999-9 Early prognosis of metastasis risk in inflammatory breast cancer by texture analysis of tumour microscopic images [Elektronische Daten] [Daniela Kolarevic, Zorica Tomasevic, Radan Dzodic, Ksenija Kanjer, Dragica Vukosavljevic, Marko Radulovic] Inflammatory breast cancer (IBC) is a rare and aggressive type of locally advanced breast cancer. The purpose of this study was to determine the value of microscopic tumour histomorphology texture for prognosis of local and systemic recurrence at the time of initial IBC diagnosis. This retrospective study included a group of 52 patients selected on the basis of non-metastatic IBC diagnosis, stage IIIB. Gray-Level-Co-Occurrence-Matrix (GLCM) texture analysis was performed on digital images of primary tumour tissue sections stained with haematoxylin/eosin. Obtained values were categorized by use of both data- and outcome-based methods. All five acquired GLCM texture features significantly associated with metastasis outcome. By accuracies of 69-81% and AUCs of 0.71-0.81, prognostic performance of GLCM parameters exceeded that of standard major IBC clinical prognosticators such as tumour grade and response to induction chemotherapy. Furthermore, a composite score consisting of tumour grade, contrast and correlation as independent features resulted in further enhancement of prognostic performance by accuracy of 89%, discrimination efficiency by AUC of 0.93 and an outstanding hazard ratio of 71.6 (95%CI, 41.7-148.4). Internal validation was successfully performed by bootstrap and split-sample cross-validation, suggesting that the model is generalizable. This study indicates for the first time the potential use of primary breast tumour histology texture as a highly accurate, simple and cost-effective prognostic indicator of metastasis risk in IBC. Clinical relevance of the obtained results rests on the role of prognosis in decisions on induction chemotherapy and the resulting impact on quality of life and survival. Springer Science+Business Media New York, 2015 Inflammatory breast cancer nationallicence Image analysis nationallicence Prognosis nationallicence Prognostic factor nationallicence Metastasis nationallicence Histology texture nationallicence GLCM nationallicence Kolarevic Daniela Daily Chemotherapy Hospital, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut Tomasevic Zorica Daily Chemotherapy Hospital, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut Dzodic Radan Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut Kanjer Ksenija Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut Vukosavljevic Dragica Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut Radulovic Marko Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-8 1387-2176 17:5<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9999-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9999-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolarevic Daniela Daily Chemotherapy Hospital, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Tomasevic Zorica Daily Chemotherapy Hospital, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Dzodic Radan Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia aut NATIONALLICENCE 700 1- Kanjer Ksenija Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Vukosavljevic Dragica Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut NATIONALLICENCE 700 1- Radulovic Marko Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-8 1387-2176 17:5<1 2015 17 10544