caa a22 4500 605480125 CHVBK 20210128100413.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10544-015-0001-7 doi (NATIONALLICENCE)springer-10.1007/s10544-015-0001-7 Piezo-actuated parallel mechanism for biological cell release at high speed [Elektronische Daten] [Ebubekir Avci, Takayuki Hattori, Kazuto Kamiyama, Masaru Kojima, Mitsuhiro Horade, Yasushi Mae, Tatsuo Arai] In this paper, a dynamic releasing approach is proposed for high-speed biological cell manipulation. A compact parallel mechanism for grasping and releasing microobjects is used to generate controllable vibration to overcome the strong adhesion forces between the end effector and the manipulated object. To reach the required acceleration of the end effector, which is necessary for the detachment of the target object by overcoming adhesion forces, vibration in the end effector is generated by applying sinusoidal voltage to the PZT actuator of the parallel mechanism. For the necessary acceleration, we focus on the possible range of the frequency of the PZT-actuator-induced vibration, while minimizing the amplitude of the vibration (14 nm) to achieve precise positioning. The effect of the air and liquid environments on the required vibration frequency for successful release is investigated. For the first time, release results of microbeads and biological cells are compared. Release of the biological cells with 100 % success rate suggests that the proposed active release method is an appropriate solution for adhered biological cells during the release task. Springer Science+Business Media New York, 2015 Cell handling nationallicence Micro-scale release nationallicence Controlled vibration nationallicence Micro-manipulation nationallicence Piezo actuator nationallicence Avci Ebubekir The Hamlyn Centre for Robotic Surgery, Imperial College London, SW7 2AZ, London, UK aut Hattori Takayuki Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Kamiyama Kazuto Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Kojima Masaru Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Horade Mitsuhiro Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Mae Yasushi Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Arai Tatsuo Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-10 1387-2176 17:5<1 2015 17 10544 https://doi.org/10.1007/s10544-015-0001-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-0001-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Avci Ebubekir The Hamlyn Centre for Robotic Surgery, Imperial College London, SW7 2AZ, London, UK aut NATIONALLICENCE 700 1- Hattori Takayuki Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 700 1- Kamiyama Kazuto Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 700 1- Kojima Masaru Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 700 1- Horade Mitsuhiro Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 700 1- Mae Yasushi Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 700 1- Arai Tatsuo Department of Systems Innovation, Osaka University, 1-3 Machikaneyama, 560-8531, Toyonaka, Osaka, Japan aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-10 1387-2176 17:5<1 2015 17 10544